Search: onr:"swepub:oai:prod.swepub.kib.ki.se:115866687" >
Improving proteinur...
Improving proteinuria, endothelial functions and asymmetric dimethylarginine levels in chronic kidney disease: ramipril versus valsartan
- Article/chapterEnglish2007
Publisher, publication year, extent ...
-
2007-08-20
-
S. Karger AG,2007
Numbers
-
LIBRIS-ID:oai:prod.swepub.kib.ki.se:115866687
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:115866687URI
-
https://doi.org/10.1159/000107410DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
<i>Background:</i> The aim of this study was to find out whether the beneficial effects of the renin-angiotensin-aldosterone system (RAS) blockage in chronic kidney disease (CKD) has any relation with the alteration of asymmetric dimethylarginine (ADMA) levels. <i>Methods:</i> Sixty-six nondiabetic patients with CKD and proteinuria and 36 healthy subjects were enrolled. Patients were treated with either ramipril 5 mg daily or valsartan 160 mg daily for 3 months. Proteinuria, ADMA, symmetric dimethyl arginine (SDMA), flow-mediated dilatation (FMD) and HOMA index measurements were performed both before and after the treatment. <i>Results:</i> ADMA, SDMA, hsCRP levels, HOMA index and proteinuria of patients were significantly higher (p < 0.001 for all) and FMD, <i>L</i>-arginine and <i>L</i>-arginine/ADMA ratio in CKD were significantly lower than controls. According to the multiple regression analysis, proteinuria levels were independently related to ADMA and SDMA levels. <i>Conclusion:</i> Both drugs were equally effective in reducing elevated ADMA levels and improving endothelial dysfunction in CKD patients.
Added entries (persons, corporate bodies, meetings, titles ...)
-
Saglam, M
(author)
-
Sonmez, A
(author)
-
Caglar, K
(author)
-
Cakir, E
(author)
-
Kurt, Y
(author)
-
Eyileten, T
(author)
-
Tasar, M
(author)
-
Acikel, C
(author)
-
Oguz, Y
(author)
-
Vural, A
(author)
-
Yenicesu, M
(author)
Related titles
-
In:Blood purification: S. Karger AG25:4, s. 327-3351421-97350253-5068
Internet link
Find in a library
To the university's database
- By the author/editor
-
Yilmaz, MI
-
Saglam, M
-
Sonmez, A
-
Caglar, K
-
Cakir, E
-
Kurt, Y
-
show more...
-
Eyileten, T
-
Tasar, M
-
Acikel, C
-
Oguz, Y
-
Vural, A
-
Yenicesu, M
-
show less...
- Articles in the publication
-
Blood purificati ...
- By the university
-
Karolinska Institutet