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Human CMV infection...
Human CMV infection induces 5-lipoxygenase expression and leukotriene B4 production in vascular smooth muscle cells
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Qiu, H (author)
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- Straat, K (author)
- Karolinska Institutet
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- Rahbar, A (author)
- Karolinska Institutet
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- Wan, M (author)
- Karolinska Institutet
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- Soderberg-Naucler, C (author)
- Karolinska Institutet
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- Haeggstrom, JZ (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2008-01-07
- 2008
- English.
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In: The Journal of experimental medicine. - : Rockefeller University Press. - 1540-9538 .- 0022-1007. ; 205:1, s. 19-24
- Related links:
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http://jem.rupress.o...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- Leukotrienes (LTs) are powerful proinflammatory lipid mediators that may play a central role in cardiovascular diseases, including arteriosclerosis, myocardial infarction, and stroke. Owing to restricted expression of 5-lipoxygenase (5-LO), the enzyme required for their synthesis, LTs are almost exclusively produced by myeloid cells. Here, we report that human cytomegalovirus (HCMV) infection of human vascular smooth muscle cells (SMCs) increases 5-LO mRNA levels by up to 170-fold in a dose- and time-dependent manner. Infected cells expressed 5-LO protein, as shown by immunohistochemistry, enabling them to synthesize bioactive LTB4. HCMV-infected vascular SMCs expressing 5-LO protein were readily detected in tissue samples from CMV-infected patients with inflammatory bowel disease or AIDS. Thus, pathogen-induced LT production in HCMV-infected tissues may contribute to local inflammation, consistent with the ability of HCMV to control cellular and immunological functions. HCMV-induced LT biosynthesis in SMCs offers a molecular mechanism to explain HCMV-induced pathogenesis in inflammatory diseases.
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- art (subject category)
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