Reduced plasma high-density lipoprotein cholesterol in hyperthyroid mice coincides with decreased hepatic adenosine 5'-triphosphate-binding cassette transporter 1 expression

Tancevski, I (author)

Wehinger, A (author)

Demetz, E (author)

Eller, P (author)

Duwensee, K (author)

Huber, J (author)

Hochegger, K (author)

Schgoer, W (author)

Fievet, C (author)

Stellaard, F (author)

Patsch, JR (author)

Ritsch, A (author)

(creator_code:org_t)

2008-04-03
2008
English.
In: Endocrinology. - : The Endocrine Society. - 0013-7227 .- 1945-7170. ; 149:7, s. 3708-3712

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Abstract Subject headings

The aim of the study was to investigate the influence of severe hyperthyroidism on plasma high-density lipoprotein cholesterol (HDL-C). Recently, it was shown in mice that increasing doses of T3 up-regulate hepatic expression of scavenger receptor class B, type I, resulting in increased clearance of plasma HDL-C. Here, we show that severe hyperthyroidism in mice did not affect hepatic expression of scavenger receptor class B, type I, but reduced hepatic expression of ATP-binding cassette transporter 1, accompanied by a 40% reduction of HDL-C. The sterol content of bile, liver, and feces was markedly increased, accompanied by up-regulation of hepatic cholesterol 7α-hydroxylase, and ATP-binding cassette transporter 5, which is known to promote biliary sterol secretion upon dimerization with ATP-binding cassette transporter 8. Both control and hyperthyroid mice exerted identical plasma clearance of iv injected [3H]HDL-C, supporting the view that severe hyperthyroidism does not affect HDL-C clearance but, rather, its formation via hepatic ATP-binding cassette transporter 1.

By the author/editor: Tancevski, I; Wehinger, A; Demetz, E; Eller, P; Duwensee, K; Huber, J; show more...; Hochegger, K; Schgoer, W; Fievet, C; Stellaard, F; Rudling, M; Patsch, JR; Ritsch, A; show less...

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