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An interferon-relat...
An interferon-related gene signature for DNA damage resistance is a predictive marker for chemotherapy and radiation for breast cancer
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Weichselbaum, RR (author)
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Ishwaran, H (author)
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Yoon, T (author)
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Nuyten, DSA (author)
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Baker, SW (author)
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Khodarev, N (author)
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Su, AW (author)
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Shaikh, AY (author)
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Roach, P (author)
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Kreike, B (author)
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Roizman, B (author)
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- Bergh, J (author)
- Karolinska Institutet
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- Pawitan, Y (author)
- Karolinska Institutet
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de Vijver, MJV (author)
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Minn, AJ (author)
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(creator_code:org_t)
- 2008-11-25
- 2008
- English.
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In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 1091-6490. ; 105:47, s. 18490-18495
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Abstract
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- Individualization of cancer management requires prognostic markers and therapy-predictive markers. Prognostic markers assess risk of disease progression independent of therapy, whereas therapy-predictive markers identify patients whose disease is sensitive or resistant to treatment. We show that an experimentally derived IFN-related DNA damage resistance signature (IRDS) is associated with resistance to chemotherapy and/or radiation across different cancer cell lines. The IRDS genes STAT1, ISG15, and IFIT1 all mediate experimental resistance. Clinical analyses reveal that IRDS(+) and IRDS(−) states exist among common human cancers. In breast cancer, a seven–gene-pair classifier predicts for efficacy of adjuvant chemotherapy and for local-regional control after radiation. By providing information on treatment sensitivity or resistance, the IRDS improves outcome prediction when combined with standard markers, risk groups, or other genomic classifiers.
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Weichselbaum, RR
-
Ishwaran, H
-
Yoon, T
-
Nuyten, DSA
-
Baker, SW
-
Khodarev, N
-
show more...
-
Su, AW
-
Shaikh, AY
-
Roach, P
-
Kreike, B
-
Roizman, B
-
Bergh, J
-
Pawitan, Y
-
de Vijver, MJV
-
Minn, AJ
-
show less...
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Proceedings of t ...
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Proceedings of t ...
- By the university
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Karolinska Institutet