Anxiety disorders and rheumatic Fever: is there an association?

Introduction:Findings suggest that obsessive-compulsive disorder (OCD) and related disorders, referred to as obsessive-compulsive spectrum disorders (OCSDs), are more common in patients with rheumatic fever (RF).Objectives:To determine whether RF or Sydenham's chorea increases the probability of anxiety disorders in the relatives of individuals with RF with and without SC.Methods:This was a case-control family study in which 98 probands and 389 first-degree relatives (FDRs) were assessed using structured psychiatric interviews. A Poisson regression model was used to determine whether the presence of any disorder in one family member influences the rate of disorders in the remaining family members.Results:Generalized anxiety disorder (GAD) occurred more frequently in the FDRs of RF probands than in those of control probands (P=.018). The presence of RF, GAD, or separation anxiety disorder in one family member significantly increased the chance of OCSDs in another member of the family.

In:CNS spectrums: Cambridge University Press (CUP)13:12, s. 1039-+1092-85292165-6509

By the author/editor: Seixas, AAA; Hounie, AG; Fossaluza, V; Curi, M; Alvarenga, PG; De Mathis, MA; show more...; De Mathis, ME; Vallada, H; Pauls, D; Pereira, CAD; Miguel, EC; show less...

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