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The graft-versus-le...
The graft-versus-leukemia effect using matched unrelated donors is not superior to HLA-identical siblings for hematopoietic stem cell transplantation
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- Ringden, O (author)
- Karolinska Institutet
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Pavletic, SZ (author)
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Anasetti, C (author)
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Barrett, AJ (author)
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Wang, T (author)
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Wang, D (author)
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Antin, JH (author)
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Di Bartolomeo, P (author)
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Bolwell, BJ (author)
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Bredeson, C (author)
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Cairo, MS (author)
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Gale, RP (author)
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Gupta, V (author)
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Hahn, T (author)
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Hale, GA (author)
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Halter, J (author)
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Jagasia, M (author)
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Litzow, MR (author)
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Locatelli, F (author)
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Marks, DI (author)
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McCarthy, PL (author)
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Cowan, MJ (author)
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Petersdorf, EW (author)
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Russell, JA (author)
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Schiller, GJ (author)
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Schouten, H (author)
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Spellman, S (author)
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Verdonck, LF (author)
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Wingard, JR (author)
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Horowitz, MM (author)
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Arora, M (author)
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(creator_code:org_t)
- American Society of Hematology, 2009
- 2009
- English.
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In: Blood. - : American Society of Hematology. - 1528-0020 .- 0006-4971. ; 113:13, s. 3110-3118
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https://europepmc.or...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- Do some patients benefit from an unrelated donor (URD) transplant because of a stronger graft-versus-leukemia (GVL) effect? We analyzed 4099 patients with acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), and chronic myeloid leukemia (CML) undergoing a myeloablative allogeneic hematopoietic cell transplantation (HCT) from an URD (8/8 human leukocyte antigen [HLA]–matched, n = 941) or HLA-identical sibling donor (n = 3158) between 1995 and 2004 reported to the CIBMTR. In the Cox regression model, acute and chronic GVHD were added as time-dependent variables. In multivariate analysis, URD transplant recipients had a higher risk for transplantation-related mortality (TRM; relative risk [RR], 2.76; P < .001) and relapse (RR, 1.50; P < .002) in patients with AML, but not ALL or CML. Chronic GVHD was associated with a lower relapse risk in all diagnoses. Leukemia-free survival (LFS) was decreased in patients with AML without acute GVHD receiving a URD transplant (RR, 2.02; P < .001) but was comparable to those receiving HLA-identical sibling transplants in patients with ALL and CML. In patients without GVHD, multivariate analysis showed similar risk of relapse but decreased LFS for URD transplants for all 3 diagnoses. In conclusion, risk of relapse was the same (ALL, CML) or worse (AML) in URD transplant recipients compared with HLA-identical sibling transplant recipients, suggesting a similar GVL effect.
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- ref (subject category)
- art (subject category)
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Blood
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To the university's database
- By the author/editor
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Ringden, O
-
Pavletic, SZ
-
Anasetti, C
-
Barrett, AJ
-
Wang, T
-
Wang, D
-
show more...
-
Antin, JH
-
Di Bartolomeo, P
-
Bolwell, BJ
-
Bredeson, C
-
Cairo, MS
-
Gale, RP
-
Gupta, V
-
Hahn, T
-
Hale, GA
-
Halter, J
-
Jagasia, M
-
Litzow, MR
-
Locatelli, F
-
Marks, DI
-
McCarthy, PL
-
Cowan, MJ
-
Petersdorf, EW
-
Russell, JA
-
Schiller, GJ
-
Schouten, H
-
Spellman, S
-
Verdonck, LF
-
Wingard, JR
-
Horowitz, MM
-
Arora, M
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show less...
- Articles in the publication
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Blood
- By the university
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Karolinska Institutet