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Heterochromatin pro...
Heterochromatin protein 1 is recruited to various types of DNA damage
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- Luijsterburg, MS (author)
- Karolinska Institutet
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Dinant, C (author)
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Lans, H (author)
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Stap, J (author)
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Wiernasz, E (author)
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Lagerwerf, S (author)
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Warmerdam, DO (author)
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Lindh, M (author)
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Brink, MC (author)
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Dobrucki, JW (author)
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Aten, JA (author)
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Fousteri, MI (author)
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Jansen, G (author)
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- Dantuma, NP (author)
- Karolinska Institutet
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Vermeulen, W (author)
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Mullenders, LHF (author)
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Houtsmuller, AB (author)
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Verschure, PJ (author)
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van Driel, R (author)
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(creator_code:org_t)
- 2009-05-18
- 2009
- English.
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In: The Journal of cell biology. - : Rockefeller University Press. - 1540-8140 .- 0021-9525. ; 185:4, s. 577-586
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http://jcb.rupress.o...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- Heterochromatin protein 1 (HP1) family members are chromatin-associated proteins involved in transcription, replication, and chromatin organization. We show that HP1 isoforms HP1-α, HP1-β, and HP1-γ are recruited to ultraviolet (UV)-induced DNA damage and double-strand breaks (DSBs) in human cells. This response to DNA damage requires the chromo shadow domain of HP1 and is independent of H3K9 trimethylation and proteins that detect UV damage and DSBs. Loss of HP1 results in high sensitivity to UV light and ionizing radiation in the nematode Caenorhabditis elegans, indicating that HP1 proteins are essential components of DNA damage response (DDR) systems. Analysis of single and double HP1 mutants in nematodes suggests that HP1 homologues have both unique and overlapping functions in the DDR. Our results show that HP1 proteins are important for DNA repair and may function to reorganize chromatin in response to damage.
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
-
Luijsterburg, MS
-
Dinant, C
-
Lans, H
-
Stap, J
-
Wiernasz, E
-
Lagerwerf, S
-
show more...
-
Warmerdam, DO
-
Lindh, M
-
Brink, MC
-
Dobrucki, JW
-
Aten, JA
-
Fousteri, MI
-
Jansen, G
-
Dantuma, NP
-
Vermeulen, W
-
Mullenders, LHF
-
Houtsmuller, AB
-
Verschure, PJ
-
van Driel, R
-
show less...
- Articles in the publication
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The Journal of c ...
- By the university
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Karolinska Institutet