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Inferring tumor pro...
Inferring tumor progression from genomic heterogeneity
- Article/chapterEnglish2010
Publisher, publication year, extent ...
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2009-11-10
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Cold Spring Harbor Laboratory,2010
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:119818354
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http://kipublications.ki.se/Default.aspx?queryparsed=id:119818354URI
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https://doi.org/10.1101/gr.099622.109DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Cancer progression in humans is difficult to infer because we do not routinely sample patients at multiple stages of their disease. However, heterogeneous breast tumors provide a unique opportunity to study human tumor progression because they still contain evidence of early and intermediate subpopulations in the form of the phylogenetic relationships. We have developed a method we call Sector-Ploidy-Profiling (SPP) to study the clonal composition of breast tumors. SPP involves macro-dissecting tumors, flow-sorting genomic subpopulations by DNA content, and profiling genomes using comparative genomic hybridization (CGH). Breast carcinomas display two classes of genomic structural variation: (1) monogenomic and (2) polygenomic. Monogenomic tumors appear to contain a single major clonal subpopulation with a highly stable chromosome structure. Polygenomic tumors contain multiple clonal tumor subpopulations, which may occupy the same sectors, or separate anatomic locations. In polygenomic tumors, we show that heterogeneity can be ascribed to a few clonal subpopulations, rather than a series of gradual intermediates. By comparing multiple subpopulations from different anatomic locations, we have inferred pathways of cancer progression and the organization of tumor growth.
Added entries (persons, corporate bodies, meetings, titles ...)
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Krasnitz, A
(author)
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Rodgers, L
(author)
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Cook, K
(author)
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Meth, J
(author)
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Kendall, J
(author)
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Riggs, M
(author)
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Eberling, Y
(author)
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Troge, J
(author)
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Grubor, V
(author)
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Levy, D
(author)
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Lundin, P
(author)
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Maner, SKarolinska Institutet
(author)
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Zetterberg, AKarolinska Institutet
(author)
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Hicks, J
(author)
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Wigler, M
(author)
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Karolinska Institutet
(creator_code:org_t)
Related titles
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In:Genome research: Cold Spring Harbor Laboratory20:1, s. 68-801549-54691088-9051
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Navin, N
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Krasnitz, A
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Rodgers, L
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Cook, K
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Meth, J
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Kendall, J
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Riggs, M
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Eberling, Y
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Troge, J
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Grubor, V
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Levy, D
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Lundin, P
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Maner, S
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Zetterberg, A
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Hicks, J
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Wigler, M
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Genome research
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Karolinska Institutet