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APOE ε2 allele is a...
APOE ε2 allele is associated with larger regional cortical thicknesses and volumes
- Article/chapterEnglish2010
Publisher, publication year, extent ...
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2010-09-15
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S. Karger AG,2010
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:121372860
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http://kipublications.ki.se/Default.aspx?queryparsed=id:121372860URI
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https://doi.org/10.1159/000320136DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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<i>Background:</i> The protective effect of the apolipoprotein E (APOE) Ε2 allele against Alzheimer’s disease (AD) is controversial. <i>Objective:</i> Our purpose was to clarify if the Ε2 allele affects regional cortical thicknesses and volumes. <i>Methods:</i> Regional cortical thicknesses and volumes were measured with an automated pipeline in 109 subjects with mild cognitive impairment, 114 AD patients and 105 age-matched healthy controls. <i>Results:</i> In the mild cognitive impairment group, the Ε2 carriers had thicker regional cortices at the transverse temporal cortex and parahippocampal gyrus than the subjects with Ε3/Ε3, and a larger cerebral gray matter and smaller lateral ventricles than the Ε3/Ε3 and Ε4 carriers. In the AD group, the Ε2 carriers had significantly thicker entorhinal and transverse temporal cortices, a larger whole cerebral gray matter, and smaller lateral ventricles than the subjects with the Ε3/Ε3 genotype, and a significantly thicker entorhinal cortex and larger cerebral gray matter than Ε4 carriers. No APOE2 effect was found in the control group. <i>Conclusion:</i> The APOE Ε2 allele is associated with larger regional cortical thicknesses and volumes in mild cognitive impairment and AD.
Added entries (persons, corporate bodies, meetings, titles ...)
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Paajanen, T
(author)
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Westman, EKarolinska Institutet
(author)
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Zhang, Y
(author)
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Wahlund, LOKarolinska Institutet
(author)
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Simmons, AKarolinska Institutet
(author)
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Tunnard, C
(author)
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Sobow, T
(author)
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Proitsi, P
(author)
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Powell, J
(author)
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Mecocci, P
(author)
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Tsolaki, M
(author)
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Vellas, B
(author)
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Muehlboeck, SKarolinska Institutet
(author)
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Evans, A
(author)
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Spenger, C
(author)
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Lovestone, S
(author)
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Soininen, H
(author)
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Karolinska Institutet
(creator_code:org_t)
Related titles
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In:Dementia and geriatric cognitive disorders: S. Karger AG30:3, s. 229-2371421-98241420-8008
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- By the author/editor
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Liu, YW
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Paajanen, T
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Westman, E
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Zhang, Y
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Wahlund, LO
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Simmons, A
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show more...
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Tunnard, C
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Sobow, T
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Proitsi, P
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Powell, J
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Mecocci, P
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Tsolaki, M
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Vellas, B
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Muehlboeck, S
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Evans, A
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Spenger, C
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Lovestone, S
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Soininen, H
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- Articles in the publication
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Dementia and ger ...
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Karolinska Institutet