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Regional difference...
Regional differences in effects of APOE ε4 on cognitive impairment in non-demented subjects
- Article/chapterEnglish2011
Publisher, publication year, extent ...
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2011-09-22
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S. Karger AG,2011
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:123378924
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http://kipublications.ki.se/Default.aspx?queryparsed=id:123378924URI
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https://doi.org/10.1159/000330492DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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<i>Background:</i> The <i>APOE</i> ε4 allele is a risk factor for Alzheimer’s disease (AD). <i>APOE</i> ε4 is common in non-demented subjects with cognitive impairment. In both healthy people and people with AD, its prevalence has a north-south gradient across Europe. In the present study, we investigated whether the relation between the <i>APOE</i> ε4 allele and cognitive impairment varied across Northern, Middle and Southern Europe. We also investigated whether a north-south gradient existed in subjects with subjective cognitive impairment (SCI), amnestic mild cognitive impairment (MCI) and non-amnestic MCI. <i>Methods:</i> Data from 16 centers across Europe were analyzed. <i>Results:</i> A north-south gradient in <i>APOE</i> ε4 prevalence existed in the total sample (62.7% for <i>APOE</i> ε4 carriers in the northern region, 42.1% in the middle region, and 31.5% in the southern region) and in subjects with SCI and amnestic MCI separately. Only in Middle Europe was the <i>APOE</i> ε4 allele significantly associated with poor performance on tests of delayed recall and learning, as well as with the amnestic subtype of MCI. <i>Conclusion:</i> The <i>APOE</i> ε4 allele frequencies in subjects with SCI and amnestic MCI have a north-south gradient. The relation between the <i>APOE</i> ε4 allele and cognition is region dependent.
Added entries (persons, corporate bodies, meetings, titles ...)
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Graff, CKarolinska Institutet
(author)
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Almkvist, OKarolinska Institutet
(author)
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Ewers, M
(author)
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Frisoni, GB
(author)
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Frolich, L
(author)
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Hampel, H
(author)
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Jones, RW
(author)
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Kehoe, PG
(author)
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Lenoir, H
(author)
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Minthon, L
(author)
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Nobili, F
(author)
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Rikkert, MO
(author)
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Rigaud, AS
(author)
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Scheltens, P
(author)
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Soininen, H
(author)
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Spiru, L
(author)
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Tsolaki, M
(author)
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Wahlund, LOKarolinska Institutet
(author)
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Vellas, B
(author)
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Wilcock, G
(author)
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Elias-Sonnenschein, LS
(author)
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Verhey, FRJ
(author)
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Visser, PJ
(author)
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Karolinska Institutet
(creator_code:org_t)
Related titles
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In:Dementia and geriatric cognitive disorders: S. Karger AG32:2, s. 135-1421421-98241420-8008
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To the university's database
- By the author/editor
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Norberg, J
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Graff, C
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Almkvist, O
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Ewers, M
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Frisoni, GB
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Frolich, L
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show more...
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Hampel, H
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Jones, RW
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Kehoe, PG
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Lenoir, H
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Minthon, L
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Nobili, F
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Rikkert, MO
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Rigaud, AS
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Scheltens, P
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Soininen, H
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Spiru, L
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Tsolaki, M
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Wahlund, LO
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Vellas, B
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Wilcock, G
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Elias-Sonnensche ...
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Verhey, FRJ
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Visser, PJ
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- Articles in the publication
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Dementia and ger ...
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Karolinska Institutet