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Corpus callosum tis...
Corpus callosum tissue loss and development of motor and global cognitive impairment: the LADIS study
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Frederiksen, KS (author)
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Garde, E (author)
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Skimminge, A (author)
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Barkhof, F (author)
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Scheltens, P (author)
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van Straaten, ECW (author)
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Fazekas, F (author)
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Baezner, H (author)
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Verdelho, A (author)
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Ferro, JM (author)
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Erkinjuntti, T (author)
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Jokinen, H (author)
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- Wahlund, LO (author)
- Karolinska Institutet
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O'Brien, JT (author)
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Basile, AM (author)
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Pantoni, L (author)
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Inzitari, D (author)
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Waldemar, G (author)
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(creator_code:org_t)
- 2012-01-19
- 2011
- English.
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In: Dementia and geriatric cognitive disorders. - : S. Karger AG. - 1421-9824 .- 1420-8008. ; 32:4, s. 279-286
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https://www.karger.c...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- <i>Objective:</i> To examine the impact of corpus callosum (CC) tissue loss on the development of global cognitive and motor impairment in the elderly. <i>Methods:</i> This study was based on the Leukoaraiosis and Disability (LADIS) study. Assessment of cognitive and motor functions and magnetic resonance imaging (MRI) were done at baseline and at a 3-year follow-up in nondemented elderly subjects. <i>Results:</i> 328 of 639 LADIS subjects had MRIs at baseline and at the 3-year follow-up, which allowed for assessment of CC. Logistic regression revealed differential tissue loss rates in posterior CC in subjects converting to dementia, compared to nonconverters (p < 0.05). Anterior and posterior CC tissue loss was significantly correlated with self-perceived memory impairment in nonconverters (p < 0.05). CC tissue loss was also significantly associated with impaired single leg stance time (p < 0.01). <i>Conclusion:</i> The present longitudinal study on CC supports the role of callosal tissue loss in the development of global cognitive as well as motor impairment.
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Frederiksen, KS
-
Garde, E
-
Skimminge, A
-
Barkhof, F
-
Scheltens, P
-
van Straaten, EC ...
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show more...
-
Fazekas, F
-
Baezner, H
-
Verdelho, A
-
Ferro, JM
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Erkinjuntti, T
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Jokinen, H
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Wahlund, LO
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O'Brien, JT
-
Basile, AM
-
Pantoni, L
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Inzitari, D
-
Waldemar, G
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show less...
- Articles in the publication
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Dementia and ger ...
- By the university
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Karolinska Institutet