Search: onr:"swepub:oai:prod.swepub.kib.ki.se:124167333" >
CYP2C19 genotype pr...
CYP2C19 genotype predicts steady state escitalopram concentration in GENDEP
-
Huezo-Diaz, P (author)
-
Perroud, N (author)
-
Spencer, EP (author)
-
show more...
-
Smith, R (author)
-
- Sim, S (author)
- Karolinska Institutet
-
Virding, S (author)
-
Uher, R (author)
-
Gunasinghe, C (author)
-
Gray, J (author)
-
Campbell, D (author)
-
Hauser, J (author)
-
Maier, W (author)
-
Marusic, A (author)
-
Rietschel, M (author)
-
Perez, J (author)
-
Giovannini, C (author)
-
Mors, O (author)
-
Mendlewicz, J (author)
-
McGuffin, P (author)
-
Farmer, AE (author)
-
- Ingelman-Sundberg, M (author)
- Karolinska Institutet
-
Craig, IW (author)
-
Aitchison, KJ (author)
-
show less...
-
(creator_code:org_t)
- 2011-09-17
- 2012
- English.
-
In: Journal of psychopharmacology (Oxford, England). - : SAGE Publications. - 1461-7285 .- 0269-8811. ; 26:3, s. 398-407
- Related links:
-
http://kipublication...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- In vitro work shows CYP2C19 and CYP2D6 contribute to the metabolism of escitalopram to its primary metabolite, N-desmethylescitalopram. We report the effect of CYP2C19 and CYP2D6 genotypes on steady state morning concentrations of escitalopram and N-desmethylescitalopram and the ratio of this metabolite to the parent drug in 196 adult patients with depression in GENDEP, a clinical pharmacogenomic trial. Subjects who had one CYP2D6 allele associated with intermediate metabolizer phenotype and one associated with poor metabolizer (i.e. IM/PM genotypic category) had a higher mean logarithm escitalopram concentration than CYP2D6 extensive metabolizers (EMs) ( p = 0.004). Older age was also associated with higher concentrations of escitalopram. Covarying for CYP2D6 and age, we found those homozygous for the CYP2C19*17 allele associated with ultrarapid metabolizer (UM) phenotype had a significantly lower mean escitalopram concentration (2-fold, p = 0.0001) and a higher mean metabolic ratio ( p = 0.0003) than EMs, while those homozygous for alleles conferring the PM phenotype had a higher mean escitalopram concentration than EMs (1.55-fold, p = 0.008). There was a significant overall association between CYP2C19 genotypic category and escitalopram concentration ( p = 0.0003; p = 0.0012 Bonferroni corrected). In conclusion, we have demonstrated an association between CYP2C19 genotype, including the CYP2C19*17 allele, and steady state escitalopram concentration.
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Huezo-Diaz, P
-
Perroud, N
-
Spencer, EP
-
Smith, R
-
Sim, S
-
Virding, S
-
show more...
-
Uher, R
-
Gunasinghe, C
-
Gray, J
-
Campbell, D
-
Hauser, J
-
Maier, W
-
Marusic, A
-
Rietschel, M
-
Perez, J
-
Giovannini, C
-
Mors, O
-
Mendlewicz, J
-
McGuffin, P
-
Farmer, AE
-
Ingelman-Sundber ...
-
Craig, IW
-
Aitchison, KJ
-
show less...
- Articles in the publication
-
Journal of psych ...
- By the university
-
Karolinska Institutet