Search: onr:"swepub:oai:prod.swepub.kib.ki.se:124602416" >
Frontotemporal deme...
Frontotemporal dementia as a frontostriatal disorder: neostriatal morphology as a biomarker and structural basis for an endophenotype
-
Looi, JCL (author)
-
Walterfang, M (author)
-
Velakoulis, D (author)
-
show more...
-
Macfarlane, MD (author)
-
Svensson, LA (author)
-
- Wahlund, LO (author)
- Karolinska Institutet
-
show less...
-
(creator_code:org_t)
- 2012-01-05
- 2012
- English.
-
In: The Australian and New Zealand journal of psychiatry. - : SAGE Publications. - 1440-1614 .- 0004-8674. ; 46:5, s. 422-434
- Related links:
-
http://kipublication...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Objective: This article reviews the evidence for a re-conceptualisation of a subtype of frontotemporal lobar degeneration (FTLD), frontotemporal dementia (FTD), as a frontostriatal disorder, working towards an endophenotype. Method: We provide an overview of the role of frontostriatal circuits relevant to FTLD and FTD, as a subset of larger-scale distributed brain networks. We discuss the role of a strategic structure in these circuits, the neostriatum. Then we review the relationship of the clinical features of FTLD to frontostriatal circuits, correlating this with neuropsychological and neuropathological data. Conclusion: The unique structure and linkages of the neostriatum make it an ideal structure for in vivo neuroimaging to understand the neuroanatomical basis of FTD. We develop a frontostriatal endophenotypic model for FTD as a platform for further investigation.
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database