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Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase to inhibition of orotidylate decarboxylase, an early event in the de novo pyrimidine nucleotide biosynthesis pathway
- Balzarini, J (author)
- Gago, F (author)
- Kulik, W (author)
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- van Kuilenburg, ABP (author)
- Peterson, MA (author)
- Robins, MJ (author)
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- 2012
- 2012
- English.
- In: The Journal of biological chemistry. - 1083-351X. ; 287:36, s. 30444-30454
- Journal article (peer-reviewed)
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