CSF inflammation and axonal damage are increased and correlate in progressive multiple sclerosis

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Christensen, JR (author)

CSF inflammation and axonal damage are increased and correlate in progressive multiple sclerosis

Article/chapterEnglish2013

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2012-11-24
SAGE Publications,2013

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LIBRIS-ID:oai:prod.swepub.kib.ki.se:126836199
http://kipublications.ki.se/Default.aspx?queryparsed=id:126836199URI
https://doi.org/10.1177/1352458512466929DOI

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Language:English
Summary in:English

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The mechanism underlying disease progression in progressive multiple sclerosis (MS) is uncertain. Pathological studies found widespread inflammation in progressive MS brains correlating with disease progression and axonal damage. Objectives: To study cerebrospinal fluid (CSF) biomarkers and clarify whether inflammation and axonal damage are associated in progressive MS. Methods: Using enzyme-linked immunosorbent assay (ELISA), we analysed CSF from 40 secondary progressive (SPMS), 21 primary progressive (PPMS), and 36 relapsing–remitting (RRMS) and 20 non-inflammatory neurological disease (NIND) patients. Twenty-two of the SPMS patients participated in an MBP8298 peptide clinical trial and had CSF follow-up after one year. Results: Compared to NIND patients, inflammatory biomarkers osteopontin and matrix metalloproteinase-9 (MMP9) were increased in all MS patients while CXCL13 was increased in RRMS and SPMS patients. Biomarkers of axonal damage (NFL) and demyelination (MBP) were increased in all MS patients. In progressive MS patients CSF levels of osteopontin and CXCL13 correlated with NFL while osteopontin and MMP9 correlated with MBP. MBP8298 treatment did not affect the levels of the biomarkers after one year of treatment. All biomarkers were continuously increased after one year of follow-up except MBP, which decreased. Conclusion: CSF biomarkers of inflammation, axonal damage and demyelination are continuously increased in progressive MS patients and correlate. These findings parallel pathology studies, emphasise a relationship between inflammation, axonal damage and demyelination and support the use of CSF biomarkers in progressive MS clinical trials.

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Bornsen, L (author)
Khademi, MKarolinska Institutet (author)
Olsson, TKarolinska Institutet (author)
Jensen, PE (author)
Sorensen, PS (author)
Sellebjerg, F (author)
Karolinska Institutet (creator_code:org_t)

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In:Multiple sclerosis (Houndmills, Basingstoke, England): SAGE Publications19:7, s. 877-8841477-09701352-4585

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By the author/editor: Christensen, JR; Bornsen, L; Khademi, M; Olsson, T; Jensen, PE; Sorensen, PS; show more...; Sellebjerg, F; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Neurology

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Rheumatology and ...

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