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Implication of IL-2...
Implication of IL-2/IL-21 region in systemic sclerosis genetic susceptibility
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Diaz-Gallo, LM (author)
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Simeon, CP (author)
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Broen, JC (author)
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Ortego-Centeno, N (author)
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Beretta, L (author)
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Vonk, MC (author)
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Carreira, PE (author)
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Vargas, S (author)
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Roman-Ivorra, JA (author)
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Gonzalez-Gay, MA (author)
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Tolosa, C (author)
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Lopez-Longo, FJ (author)
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Espinosa, G (author)
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Vicente, EF (author)
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- Hesselstrand, Roger (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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Riemekasten, G (author)
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Witte, T (author)
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Distler, JHW (author)
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Voskuyl, AE (author)
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Schuerwegh, AJ (author)
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Shiels, PG (author)
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- Nordin, A (author)
- Karolinska Institutet
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- Padyukov, L (author)
- Karolinska Institutet
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Hoffmann-Vold, AM (author)
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Scorza, R (author)
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Lunardi, C (author)
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Airo, P (author)
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van Laar, JM (author)
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Hunzelmann, N (author)
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Gathof, BS (author)
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Kreuter, A (author)
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Herrick, A (author)
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Worthington, J (author)
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Denton, CP (author)
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Zhou, XD (author)
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Arnett, FC (author)
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Fonseca, C (author)
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Koeleman, BPC (author)
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Assasi, S (author)
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Radstake, TRDJ (author)
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Mayes, MD (author)
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Martin, J (author)
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(creator_code:org_t)
- 2012-11-21
- 2013
- English.
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In: Annals of the rheumatic diseases. - : BMJ. - 1468-2060 .- 0003-4967. ; 72:7, s. 1233-1238
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http://dx.doi.org/10...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
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- The interleukin 2 (IL-2) and interleukin 21 (IL-21) locus at chromosome 4q27 has been associated with several autoimmune diseases, and both genes are related to immune system functions. The aim of this study was to evaluate the role of the IL-2/IL-21 locus in systemic sclerosis (SSc).Patients and methodsThe case control study included 4493 SSc Caucasian patients and 5856 healthy controls from eight Caucasian populations (Spain, Germany, The Netherlands, USA, Italy, Sweden, UK and Norway). Four single nucleotide polymorphisms (rs2069762, rs6822844, rs6835457 and rs907715) were genotyped using TaqMan allelic discrimination assays.ResultsWe observed evidence of association of the rs6822844 and rs907715 variants with global SSc (pc=6.6E-4 and pc=7.2E-3, respectively). Similar statistically significant associations were observed for the limited cutaneous form of the disease. The conditional regression analysis suggested that the most likely genetic variation responsible for the association was the rs6822844 polymorphism. Consistently, the rs2069762A-rs6822844T-rs6835457G-rs907715T allelic combination showed evidence of association with SSc and limited cutaneous SSc subtype (pc=1.7E-03 and pc=8E-4, respectively).ConclusionsThese results suggested that the IL-2/IL-21 locus influences the genetic susceptibility to SSc. Moreover, this study provided further support for the IL-2/IL-21 locus as a common genetic factor in autoimmune diseases.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Diaz-Gallo, LM
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Simeon, CP
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Broen, JC
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Ortego-Centeno, ...
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Beretta, L
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Vonk, MC
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show more...
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Carreira, PE
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Vargas, S
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Roman-Ivorra, JA
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Gonzalez-Gay, MA
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Tolosa, C
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Lopez-Longo, FJ
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Espinosa, G
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Vicente, EF
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Hesselstrand, Ro ...
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Riemekasten, G
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Witte, T
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Distler, JHW
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Voskuyl, AE
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Schuerwegh, AJ
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Shiels, PG
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Nordin, A
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Padyukov, L
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Hoffmann-Vold, A ...
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Scorza, R
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Lunardi, C
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Airo, P
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van Laar, JM
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Hunzelmann, N
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Gathof, BS
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Kreuter, A
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Herrick, A
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Worthington, J
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Denton, CP
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Zhou, XD
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Arnett, FC
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Fonseca, C
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Koeleman, BPC
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Assasi, S
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Radstake, TRDJ
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Mayes, MD
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Martin, J
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Annals of the rh ...
- By the university
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Karolinska Institutet
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Lund University