Search: onr:"swepub:oai:prod.swepub.kib.ki.se:126933416" >
Drug repositioning:...
Drug repositioning: a machine-learning approach through data integration
- Article/chapterEnglish2013
Publisher, publication year, extent ...
-
2013-06-22
-
Springer Science and Business Media LLC,2013
Numbers
-
LIBRIS-ID:oai:prod.swepub.kib.ki.se:126933416
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:126933416URI
-
https://doi.org/10.1186/1758-2946-5-30DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Existing computational methods for drug repositioning either rely only on the gene expression response of cell lines after treatment, or on drug-to-disease relationships, merging several information levels. However, the noisy nature of the gene expression and the scarcity of genomic data for many diseases are important limitations to such approaches. Here we focused on a drug-centered approach by predicting the therapeutic class of FDA-approved compounds, not considering data concerning the diseases. We propose a novel computational approach to predict drug repositioning based on state-of-the-art machine-learning algorithms. We have integrated multiple layers of information: i) on the distances of the drugs based on how similar are their chemical structures, ii) on how close are their targets within the protein-protein interaction network, and iii) on how correlated are the gene expression patterns after treatment. Our classifier reaches high accuracy levels (78%), allowing us to re-interpret the top misclassifications as re-classifications, after rigorous statistical evaluation. Efficient drug repurposing has the potential to significantly impact the whole field of drug development. The results presented here can significantly accelerate the translation into the clinics of known compounds for novel therapeutic uses.
Added entries (persons, corporate bodies, meetings, titles ...)
-
Zhao, Y
(author)
-
Moreira, VM
(author)
-
Tagliaferri, R
(author)
-
Kere, JKarolinska Institutet
(author)
-
D'Amato, MKarolinska Institutet
(author)
-
Greco, D
(author)
-
Karolinska Institutet
(creator_code:org_t)
Related titles
-
In:Journal of cheminformatics: Springer Science and Business Media LLC5:1, s. 30-1758-2946
Internet link
Find in a library
To the university's database