Search: onr:"swepub:oai:prod.swepub.kib.ki.se:127385758" >
Cellular programmin...
Cellular programming and reprogramming: sculpting cell fate for the production of dopamine neurons for cell therapy
- Article/chapterEnglish2012
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:prod.swepub.kib.ki.se:127385758
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:127385758URI
-
https://doi.org/10.1155/2012/412040DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Pluripotent stem cells are regarded as a promising cell source to obtain human dopamine neurons in sufficient amounts and purity for cell replacement therapy. Importantly, the success of clinical applications depends on our ability to steer pluripotent stem cells towards the right neuronal identity. In Parkinson disease, the loss of dopamine neurons is more pronounced in the ventrolateral population that projects to the sensorimotor striatum. Because synapses are highly specific, only neurons with this precise identity will contribute, upon transplantation, to the synaptic reconstruction of the dorsal striatum. Thus, understanding the developmental cell program of the mesostriatal dopamine neurons is critical for the identification of the extrinsic signals and cell-intrinsic factors that instruct and, ultimately, determine cell identity. Here, we review how extrinsic signals and transcription factors act together during development to shape midbrain cell fates. Further, we discuss how these same factors can be appliedin vitroto induce, select, and reprogram cells to the mesostriatal dopamine fate.
Added entries (persons, corporate bodies, meetings, titles ...)
-
Hedlund, EKarolinska Institutet
(author)
-
Sanchez-Pernaute, R
(author)
-
Karolinska Institutet
(creator_code:org_t)
Related titles
-
In:Stem cells international: Hindawi Limited2012, s. 412040-1687-96781687-966X
Internet link
Find in a library
To the university's database