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Teriflunomide reduc...
Teriflunomide reduces relapse-related neurological sequelae, hospitalizations and steroid use
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O'Connor, PW (author)
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Lublin, FD (author)
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Wolinsky, JS (author)
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Confavreux, C (author)
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Comi, G (author)
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Freedman, MS (author)
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- Olsson, TP (author)
- Karolinska Institutet
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Miller, AE (author)
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Dive-Pouletty, C (author)
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Bego-Le-Bagousse, G (author)
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Kappos, L (author)
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(creator_code:org_t)
- 2013-07-14
- 2013
- English.
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In: Journal of neurology. - : Springer Science and Business Media LLC. - 1432-1459 .- 0340-5354. ; 260:10, s. 2472-2480
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https://doi.org/10.1...
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Abstract
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- Multiple sclerosis (MS) relapses impose a substantial clinical and economic burden. Teriflunomide is a new oral disease-modifying therapy approved for the treatment of relapsing MS. We evaluated the effects of teriflunomide treatment on relapse-related neurological sequelae and healthcare resource use in a post hoc analysis of the Phase III TEMSO study. Confirmed relapses associated with neurological sequelae [defined by an increase in Expanded Disability Status Scale/Functional System (sequelae-EDSS/FS) ≥30 days post relapse or by the investigator (sequelae-investigator)] were analyzed in the modified intention-to-treat population (n = 1086). Relapses requiring hospitalization or intravenous (IV) corticosteroids, all hospitalizations, emergency medical facility visits (EMFV), and hospitalized nights for relapse were also assessed. Annualized rates were derived using a Poisson model with treatment, baseline EDSS strata, and region as covariates. Risks of sequelae and hospitalization per relapse were calculated as percentages and groups were compared with a χ2 test. Compared with placebo, teriflunomide reduced annualized rates of relapses with sequelae-EDSS/FS [7 mg by 32 % (p = 0.0019); 14 mg by 36 % (p = 0.0011)] and sequelae-investigator [25 % (p = 0.071); 53 % (p < 0.0001)], relapses leading to hospitalization [36 % (p = 0.015); 59 % (p < 0.0001)], and relapses requiring IV corticosteroids [29 % (p = 0.001); 34 % (p = 0.0003)]. Teriflunomide-treated patients spent fewer nights in hospital for relapse (p < 0.01). Teriflunomide 14 mg also decreased annualized rates of all hospitalizations (p = 0.01) and EMFV (p = 0.004). The impact of teriflunomide on relapse-related neurological sequelae and relapses requiring healthcare resources may translate into reduced healthcare costs.
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- By the author/editor
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O'Connor, PW
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Lublin, FD
-
Wolinsky, JS
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Confavreux, C
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Comi, G
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Freedman, MS
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show more...
-
Olsson, TP
-
Miller, AE
-
Dive-Pouletty, C
-
Bego-Le-Bagousse ...
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Kappos, L
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show less...
- Articles in the publication
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Journal of neuro ...
- By the university
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Karolinska Institutet