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Enhanced HIV-1 immu...
Enhanced HIV-1 immunotherapy by commonly arising antibodies that target virus escape variants
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Klein, F (author)
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Nogueira, L (author)
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Nishimura, Y (author)
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- Phad, G (author)
- Karolinska Institutet
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West, AP (author)
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Halper-Stromberg, A (author)
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Horwitz, JA (author)
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Gazumyan, A (author)
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Liu, C (author)
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Eisenreich, TR (author)
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Lehmann, C (author)
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Fatkenheuer, G (author)
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Williams, C (author)
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Shingai, M (author)
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Martin, MA (author)
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Bjorkman, PJ (author)
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Seaman, MS (author)
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Zolla-Pazner, S (author)
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- Hedestam, GBK (author)
- Karolinska Institutet
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Nussenzweig, MC (author)
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(creator_code:org_t)
- 2014-11-10
- 2014
- English.
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In: The Journal of experimental medicine. - : Rockefeller University Press. - 1540-9538 .- 0022-1007. ; 211:12, s. 2361-2372
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https://doi.org/10.1...
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Abstract
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- Antibody-mediated immunotherapy is effective in humanized mice when combinations of broadly neutralizing antibodies (bNAbs) are used that target nonoverlapping sites on the human immunodeficiency virus type 1 (HIV-1) envelope. In contrast, single bNAbs can control simian–human immunodeficiency virus (SHIV) infection in immune-competent macaques, suggesting that the host immune response might also contribute to the control of viremia. Here, we investigate how the autologous antibody response in intact hosts can contribute to the success of immunotherapy. We find that frequently arising antibodies that normally fail to control HIV-1 infection can synergize with passively administered bNAbs by preventing the emergence of bNAb viral escape variants.
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Klein, F
-
Nogueira, L
-
Nishimura, Y
-
Phad, G
-
West, AP
-
Halper-Stromberg ...
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show more...
-
Horwitz, JA
-
Gazumyan, A
-
Liu, C
-
Eisenreich, TR
-
Lehmann, C
-
Fatkenheuer, G
-
Williams, C
-
Shingai, M
-
Martin, MA
-
Bjorkman, PJ
-
Seaman, MS
-
Zolla-Pazner, S
-
Hedestam, GBK
-
Nussenzweig, MC
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show less...
- Articles in the publication
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The Journal of e ...
- By the university
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Karolinska Institutet