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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02342naa a2200361 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:130257644 | |
| 003 | SwePub | |
| 008 | 240829s2014 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1302576442 URI |
| 024 | 7 | a https://doi.org/10.1073/pnas.14140531112 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Almaca, J4 aut |
| 245 | 1 0 | a Young capillary vessels rejuvenate aged pancreatic islets |
| 264 | c 2014-11-17 | |
| 264 | 1 | b Proceedings of the National Academy of Sciences,c 2014 |
| 520 | a The regulation of blood glucose is a homeostatic process that declines with age, but it is unknown whether this disturbance is a consequence of intrinsic dysfunction of the regulatory organ, the pancreatic islet. In marked contrast to the widely held notion that the insulin-producing pancreatic beta cell loses function with wear and tear, and thus causes age-related disturbances in glucose homeostasis, we show that mouse and human beta cells are fully functional at advanced age. The pancreatic islet as an organ, however, is threatened by vascular senescence. Replacing the islet vasculature in aged islet grafts rejuvenates the islet and fully restores glucose homeostasis, indicating that islet blood vessels should be targeted to mitigate frail glucose homeostasis associated with aging. | |
| 700 | 1 | a Molina, J4 aut |
| 700 | 1 | a Drigo, RAE4 aut |
| 700 | 1 | a Abdulreda, MH4 aut |
| 700 | 1 | a Jeon, WB4 aut |
| 700 | 1 | a Berggren, POu Karolinska Institutet4 aut |
| 700 | 1 | a Caicedo, A4 aut |
| 700 | 1 | a Nam, HG4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Proceedings of the National Academy of Sciences of the United States of Americad : Proceedings of the National Academy of Sciencesg 111:49, s. 17612-17617q 111:49<17612-17617x 1091-6490 |
| 773 | 0 | t Proceedings of the National Academy of Sciencesd : Proceedings of the National Academy of Sciencesg 111:49, s. 17612-17617q 111:49<17612-17617x 0027-8424 |
| 856 | 4 | u https://www.pnas.org/content/pnas/111/49/17612.full.pdf |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:130257644 |
| 856 | 4 8 | u https://doi.org/10.1073/pnas.1414053111 |
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