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Relationship between oxidized LDL, IgM, and IgG autoantibodies to ox-LDL levels with recurrent cardiovascular events in Swedish patients with previous myocardial infarction
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- Crisby, M (author)
- Karolinska Institutet
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- Henareh, L (author)
- Karolinska Institutet
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- Agewall, S (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2013-11-27
- 2014
- English.
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In: Angiology. - : SAGE Publications. - 1940-1574 .- 0003-3197. ; 65:10, s. 932-936
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Abstract
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- We determined whether plasma levels of circulating oxidized low-density lipoprotein (LDL; E06), immunoglobulin (Ig) G, and IgM autoantibodies binding to malonyldialdehyde-modified LDL (MDA-LDL) may predict cardiovascular events (CVEs). Patients (n = 123) with a previous myocardial infarction (MI) were included. The primary end point was defined as any of the following: cardiovascular death from any cause, nonfatal reinfarction or stroke, percutaneous coronary intervention, coronary artery bypass grafting, and hospitalization due to angina pectoris. There were 43 CVEs during the follow-up period of 8.4 ± 3.5 years. There was no significant difference in the levels of E06 and MDA-LDL IgG between the CVE and the event-free group. However, MDA-LDL IgM levels were significantly lower in patients in the CVE group (9524 ± 6326 relative light unit [RLU]) compared with the event-free (10 975 ± 5398 RLU) group ( P = .04). In conclusion, levels of MDA-LDL IgM were associated with an increased risk of CVE in patients with a previous MI.
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