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Towards tuberculosis elimination: an action framework for low-incidence countries

Lonnroth, K (author)
Migliori, GB (author)
Abubakar, I (author)
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D'Ambrosio, L (author)
de Vries, G (author)
Diel, R (author)
Douglas, P (author)
Falzon, D (author)
Gaudreau, MA (author)
Goletti, D (author)
Ochoa, ERG (author)
Lobue, P (author)
Matteelli, A (author)
Njoo, H (author)
Solovic, I (author)
Story, A (author)
Tayeb, T (author)
van der Werf, MJ (author)
Weil, D (author)
Zellweger, JP (author)
Aziz, MA (author)
Al Lawati, MRM (author)
Aliberti, S (author)
de Onate, WA (author)
Barreira, D (author)
Bhatia, V (author)
Blasi, F (author)
Bloom, A (author)
Bruchfeld, J (author)
Karolinska Institutet
Castelli, F (author)
Centis, R (author)
Chemtob, D (author)
Cirillo, DM (author)
Colorado, A (author)
Dadu, A (author)
Dahle, UR (author)
De Paoli, L (author)
Dias, HM (author)
Duarte, R (author)
Fattorini, L (author)
Gaga, M (author)
Getahun, H (author)
Glaziou, P (author)
Goguadze, L (author)
del Granado, M (author)
Haas, W (author)
Jarvinen, A (author)
Kwon, GY (author)
Mosca, D (author)
Nahid, P (author)
Nishikiori, N (author)
Noguer, I (author)
O'Donnell, J (author)
Pace-Asciak, A (author)
Pompa, MG (author)
Popescu, GG (author)
Cordeiro, CR (author)
Ronning, K (author)
Ruhwald, M (author)
Sculier, JP (author)
Simunovic, A (author)
Smith-Palmer, A (author)
Sotgiu, G (author)
Sulis, G (author)
Torres-Duque, CA (author)
Umeki, K (author)
Uplekar, M (author)
van Weezenbeek, C (author)
Vasankari, T (author)
Vitillo, RJ (author)
Voniatis, C (author)
Wanlin, M (author)
Raviglione, MC (author)
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 (creator_code:org_t)
2015-03-31
2015
English.
In: The European respiratory journal. - : European Respiratory Society (ERS). - 1399-3003 .- 0903-1936. ; 45:4, s. 928-952
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • This paper describes an action framework for countries with low tuberculosis (TB) incidence (<100 TB cases per million population) that are striving for TB elimination. The framework sets out priority interventions required for these countries to progress first towards “pre-elimination” (<10 cases per million) and eventually the elimination of TB as a public health problem (less than one case per million). TB epidemiology in most low-incidence countries is characterised by a low rate of transmission in the general population, occasional outbreaks, a majority of TB cases generated from progression of latent TB infection (LTBI) rather than local transmission, concentration to certain vulnerable and hard-to-reach risk groups, and challenges posed by cross-border migration. Common health system challenges are that political commitment, funding, clinical expertise and general awareness of TB diminishes as TB incidence falls. The framework presents a tailored response to these challenges, grouped into eight priority action areas: 1) ensure political commitment, funding and stewardship for planning and essential services; 2) address the most vulnerable and hard-to-reach groups; 3) address special needs of migrants and cross-border issues; 4) undertake screening for active TB and LTBI in TB contacts and selected high-risk groups, and provide appropriate treatment; 5) optimise the prevention and care of drug-resistant TB; 6) ensure continued surveillance, programme monitoring and evaluation and case-based data management; 7) invest in research and new tools; and 8) support global TB prevention, care and control. The overall approach needs to be multisectorial, focusing on equitable access to high-quality diagnosis and care, and on addressing the social determinants of TB. Because of increasing globalisation and population mobility, the response needs to have both national and global dimensions.

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