SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:prod.swepub.kib.ki.se:131161578"
 

Search: onr:"swepub:oai:prod.swepub.kib.ki.se:131161578" > Identification and ...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Lu, Y (author)

Identification and function of adenosine A3 receptor in afferent arterioles

  • Article/chapterEnglish2015

Publisher, publication year, extent ...

  • American Physiological Society,2015

Numbers

  • LIBRIS-ID:oai:prod.swepub.kib.ki.se:131161578
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:131161578URI
  • https://doi.org/10.1152/ajprenal.00422.2014DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Adenosine plays an important role in regulation of renal microcirculation. All receptors of adenosine, A1, A2A, A2B, and A3, have been found in the kidney. However, little is known about the location and function of the A3 receptor in the kidney. The present study determined the expression and role of A3 receptors in mediating the afferent arteriole (Af-Art) response and studied the interaction of A3 receptors with angiotensin II (ANG II), A1 and A2 receptors on the Af-Art. We found that the A3 receptor expressed in microdissected isolated Af-Art and the mRNA levels of A3 receptor were 59% of A1. In the isolated microperfused Af-Art, A3 receptor agonist IB-MECA did not have a constrictive effect. Activation of A3 receptor dilated the preconstricted Af-Art by norepinephrine and blunted the vasoconstrictive effect of both adenosine A1 receptor activation and ANG II on the Af-Art, respectively. Selective A2 receptor antagonist (both A2A and A2B) had no effect on A3 receptor agonist-induced vasodilation, indicating that the dilatory effect of A3 receptor activation is not mediated by activation of A2 receptor. We conclude that the A3 receptor is expressed in the Af-Art, and activation of the A3 receptor dilates the Af-Art.

Added entries (persons, corporate bodies, meetings, titles ...)

  • Zhang, R (author)
  • Ge, Y (author)
  • Carlstrom, MKarolinska Institutet (author)
  • Wang, SH (author)
  • Fu, YL (author)
  • Cheng, L (author)
  • Wei, J (author)
  • Roman, RJ (author)
  • Wang, L (author)
  • Gao, XC (author)
  • Liu, RS (author)
  • Karolinska Institutet (creator_code:org_t)

Related titles

  • In:American journal of physiology. Renal physiology: American Physiological Society308:9, s. F1020-F10251522-14661931-857X

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Search outside SwePub

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view