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Glucagon-like recep...
Glucagon-like receptor 1 agonists and DPP-4 inhibitors: potential therapies for the treatment of stroke
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- Darsalia, V (author)
- Karolinska Institutet
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- Larsson, M (author)
- Karolinska Institutet
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- Nathanson, D (author)
- Karolinska Institutet
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Klein, T (author)
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- Nystrom, T (author)
- Karolinska Institutet
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- Patrone, C (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2015-02-11
- 2015
- English.
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In: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. - : SAGE Publications. - 1559-7016. ; 35:5, s. 718-723
- Related links:
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https://journals.sag...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- During the past decades, candidate drugs that have shown neuroprotective efficacy in the preclinical setting have failed in clinical stroke trials. As a result, no treatment for stroke based on neuroprotection is available today. The activation of the glucagon-like peptide 1 receptor (GLP-1) for reducing stroke damage is a relatively novel concept that has shown neuroprotective effects in animal models. In addition, clinical studies are currently ongoing. Herein, we review this emerging research field and discuss the next milestones to be achieved to develop a novel antistroke therapy.
Publication and Content Type
- ref (subject category)
- art (subject category)
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