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Identification of f...
Identification of four new susceptibility loci for testicular germ cell tumour
- Article/chapterEnglish2015
Publisher, publication year, extent ...
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2015-10-27
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Springer Science and Business Media LLC,2015
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:132476333
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http://kipublications.ki.se/Default.aspx?queryparsed=id:132476333URI
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https://doi.org/10.1038/ncomms9690DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Genome-wide association studies (GWAS) have identified multiple risk loci for testicular germ cell tumour (TGCT), revealing a polygenic model of disease susceptibility strongly influenced by common variation. To identify additional single-nucleotide polymorphisms (SNPs) associated with TGCT, we conducted a multistage GWAS with a combined data set of >25,000 individuals (6,059 cases and 19,094 controls). We identified new risk loci for TGCT at 3q23 (rs11705932, TFDP2, P=1.5 × 10−9), 11q14.1 (rs7107174, GAB2, P=9.7 × 10−11), 16p13.13 (rs4561483, GSPT1, P=1.6 × 10−8) and 16q24.2 (rs55637647, ZFPM1, P=3.4 × 10−9). We additionally present detailed functional analysis of these loci, identifying a statistically significant relationship between rs4561483 risk genotype and increased GSPT1 expression in TGCT patient samples. These findings provide additional support for a polygenic model of TGCT risk and further insight into the biological basis of disease development.
Added entries (persons, corporate bodies, meetings, titles ...)
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Holroyd, A
(author)
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Lloyd, A
(author)
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Broderick, P
(author)
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Nsengimana, J
(author)
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Eeles, R
(author)
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Easton, DF
(author)
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Dudakia, D
(author)
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Bishop, DT
(author)
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Reid, A
(author)
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Huddart, RA
(author)
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Grotmol, T
(author)
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Wiklund, FKarolinska Institutet
(author)
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Shipley, J
(author)
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Houlston, RS
(author)
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Turnbull, C
(author)
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Karolinska Institutet
(creator_code:org_t)
Related titles
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In:Nature communications: Springer Science and Business Media LLC6, s. 8690-2041-1723
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Litchfield, K
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Holroyd, A
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Lloyd, A
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Broderick, P
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Nsengimana, J
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Eeles, R
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Easton, DF
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Dudakia, D
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Bishop, DT
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Reid, A
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Huddart, RA
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Grotmol, T
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Wiklund, F
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Shipley, J
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Houlston, RS
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Turnbull, C
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Nature communica ...
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Karolinska Institutet