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- Artigas, MS (author)
Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation
- Article/chapterEnglish2015
Publisher, publication year, extent ...
- 2015-12-04
- Springer Science and Business Media LLC,2015
Numbers
- LIBRIS-ID:oai:prod.swepub.kib.ki.se:132744286
- http://kipublications.ki.se/Default.aspx?queryparsed=id:132744286URI
- https://doi.org/10.1038/ncomms9658DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-275522URI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5 × 10−8) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1 and AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered.
Subject headings and genre
- NATURVETENSKAP Biologi Genetik hsv//swe
- NATURAL SCIENCES Biological Sciences Genetics hsv//eng
Added entries (persons, corporate bodies, meetings, titles ...)
- Lind, LarsUppsala universitet,Kardiovaskulär epidemiologi(Swepub:uu)larslind (author)
- Miller, S (author)
- Kheirallah, AK (author)
- Huffman, JE (author)
- Ntalla, I (author)
- Shrine, N (author)
- Obeidat, M (author)
- Trochet, H (author)
- McArdle, WL (author)
- Alves, AC (author)
- Hui, J (author)
- Zhao, JH (author)
- Joshi, PK (author)
- Teumer, A (author)
- Albrecht, E (author)
- Imboden, M (author)
- Rawal, R (author)
- Lopez, LM (author)
- Marten, J (author)
- Enroth, StefanUppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab,Gyllensten(Swepub:uu)stenr451 (author)
- Surakka, I (author)
- Polasek, O (author)
- Lyytikainen, LP (author)
- Granell, R (author)
- Hysi, PG (author)
- Flexeder, C (author)
- Mahajan, A (author)
- Beilby, J (author)
- Bosse, Y (author)
- Brandsma, CA (author)
- Campbell, H (author)
- Gieger, C (author)
- Glaser, S (author)
- Gonzalez, JR (author)
- Grallert, H (author)
- Hammond, CJ (author)
- Harris, SE (author)
- Hartikainen, AL (author)
- Heliovaara, M (author)
- Henderson, J (author)
- Hocking, L (author)
- Horikoshi, M (author)
- Hutri-Kahonen, N (author)
- Ingelsson, ErikUppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi(Swepub:uu)ering425 (author)
- Johansson, ÅsaUppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)asjoh108 (author)
- Kemp, JP (author)
- Kolcic, I (author)
- Kumar, A (author)
- Lind, L (author)
- Melen, EKarolinska Institutet (author)
- Musk, AW (author)
- Navarro, P (author)
- Nickle, DC (author)
- Padmanabhan, S (author)
- Raitakari, OT (author)
- Ried, JS (author)
- Ripatti, S (author)
- Schulz, H (author)
- Scott, RA (author)
- Sin, DD (author)
- Starr, JM (author)
- Vinuela, A (author)
- Volzke, H (author)
- Wild, SH (author)
- Wright, AF (author)
- Zemunik, T (author)
- Jarvis, DL (author)
- Spector, TD (author)
- Evans, DM (author)
- Lehtimaki, T (author)
- Vitart, V (author)
- Kahonen, M (author)
- Gyllensten, UlfUppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab(Swepub:uu)ulfgyll (author)
- Rudan, I (author)
- Deary, IJ (author)
- Karrasch, S (author)
- Probst-Hensch, NM (author)
- Heinrich, J (author)
- Stubbe, B (author)
- Wilson, JF (author)
- Wareham, NJ (author)
- James, AL (author)
- Morris, AP (author)
- Jarvelin, MR (author)
- Hayward, C (author)
- Sayers, I (author)
- Strachan, DP (author)
- Hall, IP (author)
- Tobin, MD (author)
- Deloukas, P (author)
- Hansell, AL (author)
- Hubbard, R (author)
- Jackson, VE (author)
- Marchini, J (author)
- Pavord, I (author)
- Thomson, NC (author)
- Zeggini, E (author)
- Uppsala universitetKardiovaskulär epidemiologi (creator_code:org_t)
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- In:Nature communications: Springer Science and Business Media LLC6, s. 8658-2041-1723
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- By the author/editor
- Artigas, MS
- Lind, Lars
- Miller, S
- Kheirallah, AK
- Huffman, JE
- Ntalla, I
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- Shrine, N
- Obeidat, M
- Trochet, H
- McArdle, WL
- Alves, AC
- Hui, J
- Zhao, JH
- Joshi, PK
- Teumer, A
- Albrecht, E
- Imboden, M
- Rawal, R
- Lopez, LM
- Marten, J
- Enroth, Stefan
- Surakka, I
- Polasek, O
- Lyytikainen, LP
- Granell, R
- Hysi, PG
- Flexeder, C
- Mahajan, A
- Beilby, J
- Bosse, Y
- Brandsma, CA
- Campbell, H
- Gieger, C
- Glaser, S
- Gonzalez, JR
- Grallert, H
- Hammond, CJ
- Harris, SE
- Hartikainen, AL
- Heliovaara, M
- Henderson, J
- Hocking, L
- Horikoshi, M
- Hutri-Kahonen, N
- Ingelsson, Erik
- Johansson, Åsa
- Kemp, JP
- Kolcic, I
- Kumar, A
- Lind, L
- Melen, E
- Musk, AW
- Navarro, P
- Nickle, DC
- Padmanabhan, S
- Raitakari, OT
- Ried, JS
- Ripatti, S
- Schulz, H
- Scott, RA
- Sin, DD
- Starr, JM
- Vinuela, A
- Volzke, H
- Wild, SH
- Wright, AF
- Zemunik, T
- Jarvis, DL
- Spector, TD
- Evans, DM
- Lehtimaki, T
- Vitart, V
- Kahonen, M
- Gyllensten, Ulf
- Rudan, I
- Deary, IJ
- Karrasch, S
- Probst-Hensch, N ...
- Heinrich, J
- Stubbe, B
- Wilson, JF
- Wareham, NJ
- James, AL
- Morris, AP
- Jarvelin, MR
- Hayward, C
- Sayers, I
- Strachan, DP
- Hall, IP
- Tobin, MD
- Deloukas, P
- Hansell, AL
- Hubbard, R
- Jackson, VE
- Marchini, J
- Pavord, I
- Thomson, NC
- Zeggini, E
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