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Plasma protein biom...
Plasma protein biomarkers of Alzheimer's disease endophenotypes in asymptomatic older twins: early cognitive decline and regional brain volumes
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Kiddle, SJ (author)
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Steves, CJ (author)
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Mehta, M (author)
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- Simmons, A (author)
- Karolinska Institutet
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Xu, X (author)
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Newhouse, S (author)
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Sattlecker, M (author)
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Ashton, NJ (author)
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Bazenet, C (author)
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Killick, R (author)
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Adnan, J (author)
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- Westman, E (author)
- Karolinska Institutet
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Nelson, S (author)
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Soininen, H (author)
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Kloszewska, I (author)
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Mecocci, P (author)
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Tsolaki, M (author)
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Vellas, B (author)
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Curtis, C (author)
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Breen, G (author)
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Williams, SCR (author)
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Lovestone, S (author)
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Spector, TD (author)
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Dobson, RJB (author)
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(creator_code:org_t)
- 2015-06-16
- 2015
- English.
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In: Translational psychiatry. - : Springer Science and Business Media LLC. - 2158-3188. ; 5, s. e584-
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https://www.nature.c...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- There is great interest in blood-based markers of Alzheimer’s disease (AD), especially in its pre-symptomatic stages. Therefore, we aimed to identify plasma proteins whose levels associate with potential markers of pre-symptomatic AD. We also aimed to characterise confounding by genetics and the effect of genetics on blood proteins in general. Panel-based proteomics was performed using SOMAscan on plasma samples from TwinsUK subjects who are asymptomatic for AD, measuring the level of 1129 proteins. Protein levels were compared with 10-year change in CANTAB-paired associates learning (PAL; n=195), and regional brain volumes (n=34). Replication of proteins associated with regional brain volumes was performed in 254 individuals from the AddNeuroMed cohort. Across all the proteins measured, genetic factors were found to explain ~26% of the variability in blood protein levels on average. The plasma level of the mitogen-activated protein kinase (MAPK) MAPKAPK5 protein was found to positively associate with the 10-year change in CANTAB-PAL in both the individual and twin difference context. The plasma level of protein MAP2K4 was found to suggestively associate negatively (Q<0.1) with the volume of the left entorhinal cortex. Future studies will be needed to assess the specificity of MAPKAPK5 and MAP2K4 to eventual conversion to AD.
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Kiddle, SJ
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Steves, CJ
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Mehta, M
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Simmons, A
-
Xu, X
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Newhouse, S
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show more...
-
Sattlecker, M
-
Ashton, NJ
-
Bazenet, C
-
Killick, R
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Adnan, J
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Westman, E
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Nelson, S
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Soininen, H
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Kloszewska, I
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Mecocci, P
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Tsolaki, M
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Vellas, B
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Curtis, C
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Breen, G
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Williams, SCR
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Lovestone, S
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Spector, TD
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Dobson, RJB
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show less...
- Articles in the publication
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Translational ps ...
- By the university
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Karolinska Institutet