Search: onr:"swepub:oai:prod.swepub.kib.ki.se:133061347" >
Predicting Nonhemol...
Predicting Nonhemolytic Neonatal Hyperbilirubinemia
-
- Norman, M (author)
- Karolinska Institutet
-
- Aberg, K (author)
- Karolinska Institutet
-
Holmsten, K (author)
-
show more...
-
Weibel, V (author)
-
- Ekeus, C (author)
- Karolinska Institutet
-
show less...
-
(creator_code:org_t)
- 2015-12-01
- 2015
- English.
-
In: Pediatrics. - : American Academy of Pediatrics (AAP). - 1098-4275 .- 0031-4005. ; 136:6, s. 1087-1094
- Related links:
-
http://kipublication...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Before hospital discharge, newborn infants should be assessed for the risk of excessive hyperbilirubinemia. We determined maternal and obstetric risk factors for hyperbilirubinemia in infants born at term (gestational age ≥37 weeks) to form an individualized risk assessment tool for clinical use.METHODS:This was a population-based study with data from the Swedish Medical Birth Register from 1999 to 2012, including 1 261 948 singleton infants. Outcome was defined as infants diagnosed with hyperbilirubinemia (N = 23 711), excluding all cases of hemolytic (immune-mediated or other specified hemolytic) diseases of the newborn.RESULTS:Risk factors with an adjusted odds ratio (aOR) for neonatal hyperbilirubinemia of ≥1.5 (medium-sized effect or more) were gestational age 37 to 38 weeks (aOR = 2.83), failed vacuum extraction (aOR = 2.79), vacuum extraction (aOR = 2.22), Asian mother (aOR = 2.09), primipara (aOR = 2.06), large-for-gestational-age infant (aOR = 1.84), obese mother (aOR = 1.83), and small-for-gestational-age infant (aOR = 1.66). Planned cesarean delivery (CD) was associated with a reduced risk (aOR = 0.45). Without any of these risk factors (normal birth weight infant delivered vaginally at 39 to 41 weeks’ gestation by a non-Asian, nonobese, multiparous mother) the rate of nonhemolytic neonatal hyperbilirubinemia was 0.7%. In relation to the combined load of different risk factors, rates of neonatal hyperbilirubinemia ranged from 0.2% to 25%.CONCLUSIONS:Collection of a few easily available maternal and obstetric risk factors predicts >100-fold variation in the incidence of neonatal hyperbilirubinemia. The information provided herein enables individualized risk prediction with interactions between different risk factors taken into account.
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
-
Pediatrics
(Search for host publication in LIBRIS)
To the university's database