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A 10-year follow-up...
A 10-year follow-up of the European multicenter trial of interferon β-1b in secondary-progressive multiple sclerosis
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Kuhle, J (author)
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Hardmeier, M (author)
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Disanto, G (author)
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Gugleta, K (author)
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Ecsedi, M (author)
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Lienert, C (author)
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Amato, MP (author)
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Baum, K (author)
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Buttmann, M (author)
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Bayas, A (author)
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Brassat, D (author)
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Brochet, B (author)
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Confavreux, C (author)
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Edan, G (author)
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Farkkila, M (author)
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- Fredrikson, S (author)
- Karolinska Institutet
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Frontoni, M (author)
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D'Hooghe, M (author)
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Hutchinson, M (author)
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De Keyser, J (author)
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Kieseier, BC (author)
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Kumpfel, T (author)
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Rio, J (author)
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Polman, C (author)
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Roullet, E (author)
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Stolz, C (author)
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Vass, K (author)
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Wandinger, KP (author)
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Kappos, L (author)
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(creator_code:org_t)
- 2015-09-11
- 2016
- English.
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In: Multiple sclerosis (Houndmills, Basingstoke, England). - : SAGE Publications. - 1477-0970 .- 1352-4585. ; 22:4, s. 533-543
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https://helda.helsin...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- To explore long-term effects of treatment and prognostic relevance of variables assessed at baseline and during the European secondary progressive multiple sclerosis (SPMS) trial of interferon beta 1b (IFNB-1b). Methods: We assessed 362 patients (60% female; median age 41 years; Expanded Disability Status Scale (EDSS): 5.5; 51% randomized to IFNB-1b) for their EDSS and treatment history after 10 years. Non-parametric analysis of covariance (ANCOVA) and multivariate linear regression models were applied. Results: Median EDSS was 6.0 at the end of the randomized controlled trial (RCT), in the IFNB-1b and placebo groups, and 7.0 in long-term follow-up patients (those receiving IFNB-1b in the RCT were 6.5 and those receiving placebo in the RCT were 7.0; p = 0.086). 24 patients (6.6%) were deceased. The EDSS at baseline and the EDSS change during the RCT were the most important predictors of the EDSS 10 years later (partial R2: 0.47). The ability to predict changes in EDSS 10 years after the RCT was limited ( R2: 0.12). Magnetic resonance imaging (MRI) measures remained in the predictive models, but explained < 5% of the variability. Conclusions: The results from this analysis did not provide convincing evidence to support a favorable long-term outcome in those patients allocated IFNB-1b during the RCT, in our SPMS cohort. The progressive stage of the disease remains largely unpredictable by clinical and conventional MRI measures, so better prognostic markers are needed.
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- art (subject category)
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- By the author/editor
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Kuhle, J
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Hardmeier, M
-
Disanto, G
-
Gugleta, K
-
Ecsedi, M
-
Lienert, C
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show more...
-
Amato, MP
-
Baum, K
-
Buttmann, M
-
Bayas, A
-
Brassat, D
-
Brochet, B
-
Confavreux, C
-
Edan, G
-
Farkkila, M
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Fredrikson, S
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Frontoni, M
-
D'Hooghe, M
-
Hutchinson, M
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De Keyser, J
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Kieseier, BC
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Kumpfel, T
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Rio, J
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Polman, C
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Roullet, E
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Stolz, C
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Vass, K
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Wandinger, KP
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Kappos, L
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show less...
- Articles in the publication
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Multiple scleros ...
- By the university
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Karolinska Institutet