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Inverse Relationshi...
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Corona-Meraz, FI
(author)
Inverse Relationship of the CMKLR1 Relative Expression and Chemerin Serum Levels in Obesity with Dysmetabolic Phenotype and Insulin Resistance
- Article/chapterEnglish2016
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:133463449
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http://kipublications.ki.se/Default.aspx?queryparsed=id:133463449URI
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https://doi.org/10.1155/2016/3085390DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Background. In obesity there is a subclinical chronic low-grade inflammatory response where insulin resistance (IR) may develop. Chemerin is secreted in white adipose tissue and promotes low-grade inflammatory process, where it expressedCMKLR1receptor. The role of chemerin andCMKLR1in inflammatory process secondary to obesity is not defined yet.Methods. Cross-sectional study with 134 individuals classified as with and without obesity by body mass index (BMI) and IR. Body fat storage measurements and metabolic and inflammatory markers were measured by routine methods. Soluble chemerin and basal levels of insulin by ELISA and relative expression ofCMKLR1were evaluated with qPCR and2-ΔΔCTmethod.Results. Differences (P<0.05) were observed between obesity and lean individuals in body fat storage measurements and metabolic-inflammatory markers. BothCMKLR1expression and chemerin levels were increased in obesity without IR. Soluble chemerin levels correlate with adiposity and metabolic markers (r=8.8% to 38.5%),P<0.05.Conclusion. The increment ofCMKLR1expression was associated with insulin production. Increased serum levels of chemerin in obesity were observed, favoring a dysmetabolic response. The results observed in this study suggest that both chemerin andCMKLR1have opposite expression in the context of low-grade inflammatory response manifested in the development of IR.
Added entries (persons, corporate bodies, meetings, titles ...)
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Navarro-Hernandez, RE
(author)
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Ruiz-Quezada, SL
(author)
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Madrigal-Ruiz, PM
(author)
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Castro-Albarran, J
(author)
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Chavarria-Avila, E
(author)
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Guzman-Ornelas, MO
(author)
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Gomez-Banuelos, E
(author)
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Petri, MH
(author)
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Ramirez-Cedano, JI
(author)
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Aguilar-Aldrete, ME
(author)
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Rios-Ibarra, C
(author)
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Vazquez-Del Mercado, M
(author)
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In:Mediators of inflammation: Hindawi Limited2016, s. 3085390-1466-18610962-9351
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