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CTCF contributes in...
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Hernandez-Hernandez, A
(author)
CTCF contributes in a critical way to spermatogenesis and male fertility
- Article/chapterEnglish2016
Publisher, publication year, extent ...
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2016-06-27
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Springer Science and Business Media LLC,2016
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:133801697
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http://kipublications.ki.se/Default.aspx?queryparsed=id:133801697URI
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https://doi.org/10.1038/srep28355DOI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The CCCTC-binding factor (CTCF) is an architectural protein that governs chromatin organization and gene expression in somatic cells. Here, we show that CTCF regulates chromatin compaction necessary for packaging of the paternal genome into mature sperm. Inactivation of Ctcf in male germ cells in mice (Ctcf-cKO mice) resulted in impaired spermiogenesis and infertility. Residual spermatozoa in Ctcf-cKO mice displayed abnormal head morphology, aberrant chromatin compaction, impaired protamine 1 incorporation into chromatin and accelerated histone depletion. Thus, CTCF regulates chromatin organization during spermiogenesis, contributing to the functional organization of mature sperm.
Added entries (persons, corporate bodies, meetings, titles ...)
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Lilienthal, IKarolinska Institutet
(author)
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Fukuda, N
(author)
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Galjart, N
(author)
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Hoog, CKarolinska Institutet
(author)
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Karolinska Institutet
(creator_code:org_t)
Related titles
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In:Scientific reports: Springer Science and Business Media LLC6, s. 28355-2045-2322
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