Search: onr:"swepub:oai:prod.swepub.kib.ki.se:133918005" >
Distinct oligoclona...
Distinct oligoclonal band antibodies in multiple sclerosis recognize ubiquitous self-proteins
-
Brandle, SM (author)
-
Obermeier, B (author)
-
Senel, M (author)
-
show more...
-
Bruder, J (author)
-
Mentele, R (author)
-
- Khademi, M (author)
- Karolinska Institutet
-
- Olsson, T (author)
- Karolinska Institutet
-
Tumani, H (author)
-
Kristoferitsch, W (author)
-
Lottspeich, F (author)
-
Wekerle, H (author)
-
Hohlfeld, R (author)
-
Dornmair, K (author)
-
show less...
-
(creator_code:org_t)
- 2016-06-20
- 2016
- English.
-
In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 1091-6490. ; 113:28, s. 7864-7869
- Related links:
-
https://www.pnas.org...
-
show more...
-
http://kipublication...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Oligoclonal bands (OCBs) of the cerebrospinal fluid (CSF) are a hallmark of multiple sclerosis (MS). They are expanded antibody species that are detectable in >95% of patients. Because several OCB and polyclonal antibodies are present in a CSF sample, it was for technical reasons thus far not possible to isolate distinct OCBs and identify their antigens. Here we combined refined biochemical analysis, proteomics, and transcriptomics to molecularly characterize distinct OCB antibodies. We produced six recombinant OCB antibodies and characterized three autoantigens. All of them were ubiquitous intracellular proteins, not specific to brain tissue. This finding indicates that in MS, part of the OCBs do not directly mediate tissue destruction, but rather, indicate a secondary immune response.
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Brandle, SM
-
Obermeier, B
-
Senel, M
-
Bruder, J
-
Mentele, R
-
Khademi, M
-
show more...
-
Olsson, T
-
Tumani, H
-
Kristoferitsch, ...
-
Lottspeich, F
-
Wekerle, H
-
Hohlfeld, R
-
Dornmair, K
-
show less...
- Articles in the publication
-
Proceedings of t ...
-
Proceedings of t ...
- By the university
-
Karolinska Institutet