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Endothelial PDGF-CC...
Endothelial PDGF-CC regulates angiogenesis-dependent thermogenesis in beige fat
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- Seki, T (author)
- Karolinska Institutet
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- Hosaka, K (author)
- Karolinska Institutet
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- Lim, S (author)
- Karolinska Institutet
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- Fischer, C (author)
- Karolinska Institutet
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Honek, J (author)
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Yang, YL (author)
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- Andersson, P (author)
- Karolinska Institutet
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Nakamura, M (author)
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- Naslund, E (author)
- Karolinska Institutet
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Yla-Herttuala, S (author)
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Sun, ML (author)
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Iwamoto, H (author)
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Li, XR (author)
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Liu, YZ (author)
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Samani, NJ (author)
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- Cao, YH (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2016-08-05
- 2016
- English.
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In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7, s. 12152-
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Abstract
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- Cold- and β3-adrenoceptor agonist-induced sympathetic activation leads to angiogenesis and UCP1-dependent thermogenesis in mouse brown and white adipose tissues. Here we show that endothelial production of PDGF-CC during white adipose tissue (WAT) angiogenesis regulates WAT browning. We find that genetic deletion of endothelial VEGFR2, knockout of the Pdgf-c gene or pharmacological blockade of PDGFR-α impair the WAT-beige transition. We further show that PDGF-CC stimulation upregulates UCP1 expression and acquisition of a beige phenotype in differentiated mouse WAT-PDGFR-α+ progenitor cells, as well as in human WAT-PDGFR-α+ adipocytes, supporting the physiological relevance of our findings. Our data reveal a paracrine mechanism by which angiogenic endothelial cells modulate adipocyte metabolism, which may provide new targets for the treatment of obesity and related metabolic diseases.
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- art (subject category)
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- By the author/editor
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Seki, T
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Hosaka, K
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Lim, S
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Fischer, C
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Honek, J
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Yang, YL
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show more...
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Andersson, P
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Nakamura, M
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Naslund, E
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Yla-Herttuala, S
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Sun, ML
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Iwamoto, H
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Li, XR
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Liu, YZ
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Samani, NJ
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Cao, YH
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show less...
- Articles in the publication
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Nature communica ...
- By the university
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Karolinska Institutet