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  • Seki, TKarolinska Institutet (author)

Endothelial PDGF-CC regulates angiogenesis-dependent thermogenesis in beige fat

  • Article/chapterEnglish2016

Publisher, publication year, extent ...

  • 2016-08-05
  • Springer Science and Business Media LLC,2016

Numbers

  • LIBRIS-ID:oai:prod.swepub.kib.ki.se:133999174
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:133999174URI
  • https://doi.org/10.1038/ncomms12152DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Cold- and β3-adrenoceptor agonist-induced sympathetic activation leads to angiogenesis and UCP1-dependent thermogenesis in mouse brown and white adipose tissues. Here we show that endothelial production of PDGF-CC during white adipose tissue (WAT) angiogenesis regulates WAT browning. We find that genetic deletion of endothelial VEGFR2, knockout of the Pdgf-c gene or pharmacological blockade of PDGFR-α impair the WAT-beige transition. We further show that PDGF-CC stimulation upregulates UCP1 expression and acquisition of a beige phenotype in differentiated mouse WAT-PDGFR-α+ progenitor cells, as well as in human WAT-PDGFR-α+ adipocytes, supporting the physiological relevance of our findings. Our data reveal a paracrine mechanism by which angiogenic endothelial cells modulate adipocyte metabolism, which may provide new targets for the treatment of obesity and related metabolic diseases.

Added entries (persons, corporate bodies, meetings, titles ...)

  • Hosaka, KKarolinska Institutet (author)
  • Lim, SKarolinska Institutet (author)
  • Fischer, CKarolinska Institutet (author)
  • Honek, J (author)
  • Yang, YL (author)
  • Andersson, PKarolinska Institutet (author)
  • Nakamura, M (author)
  • Naslund, EKarolinska Institutet (author)
  • Yla-Herttuala, S (author)
  • Sun, ML (author)
  • Iwamoto, H (author)
  • Li, XR (author)
  • Liu, YZ (author)
  • Samani, NJ (author)
  • Cao, YHKarolinska Institutet (author)
  • Karolinska Institutet (creator_code:org_t)

Related titles

  • In:Nature communications: Springer Science and Business Media LLC7, s. 12152-2041-1723

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