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BAFF-secreting neut...
BAFF-secreting neutrophils drive plasma cell responses during emergency granulopoiesis
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- Parsa, R (author)
- Karolinska Institutet
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- Lund, H (author)
- Karolinska Institutet
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- Georgoudaki, AM (author)
- Karolinska Institutet
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- Zhang, XM (author)
- Karolinska Institutet
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- Guerreiro-Cacais, AO (author)
- Karolinska Institutet
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- Grommisch, D (author)
- Karolinska Institutet
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Warnecke, A (author)
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Croxford, AL (author)
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- Jagodic, M (author)
- Karolinska Institutet
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Becher, B (author)
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- Karlsson, MCI (author)
- Karolinska Institutet
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- Harris, RA (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2016-07-18
- 2016
- English.
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In: The Journal of experimental medicine. - : Rockefeller University Press. - 1540-9538 .- 0022-1007. ; 213:8, s. 1537-1553
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https://doi.org/10.1...
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Abstract
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- Prolonged infections or adjuvant usage can trigger emergency granulopoiesis (EG), leading to dysregulation in neutrophil blood counts. However, the impact of EG on T and B cell function remains largely unknown. In this study, to address this question, we used a mouse model of neutropenia and studied immune activation after adjuvant administration. The initial neutropenic state fostered an environment of increased dendritic cell activation and T cell–derived IL-17 production. Interestingly, neutropenic lysozyme 2–diphtheria toxin A mice exhibited striking EG and amplified neutrophil recruitment to the lymph nodes (LNs) that was dependent on IL-17–induced prostaglandin activity. The recruited neutrophils secreted a B cell–activating factor that highly accelerated plasma cell generation and antigen-specific antibody production. Reduction of neutrophil functions via granulocyte colony-stimulating factor neutralization significantly diminished plasma cell formation, directly linking EG with the humoral immune response. We conclude that neutrophils are capable of directly regulating T cell–dependent B cell responses in the LN.
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- art (subject category)
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- By the author/editor
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Parsa, R
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Lund, H
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Georgoudaki, AM
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Zhang, XM
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Guerreiro-Cacais ...
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Grommisch, D
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show more...
-
Warnecke, A
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Croxford, AL
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Jagodic, M
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Becher, B
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Karlsson, MCI
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Harris, RA
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show less...
- Articles in the publication
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The Journal of e ...
- By the university
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Karolinska Institutet