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ECIL guidelines for...
ECIL guidelines for preventing Pneumocystis jirovecii pneumonia in patients with haematological malignancies and stem cell transplant recipients
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Maertens, J (author)
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Cesaro, S (author)
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Maschmeyer, G (author)
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Einsele, H (author)
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Donnelly, JP (author)
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Alanio, A (author)
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Hauser, PM (author)
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Lagrou, K (author)
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Melchers, WJG (author)
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Helweg-Larsen, J (author)
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Matos, O (author)
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Bretagne, S (author)
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Cordonnier, C (author)
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- 2016-05-12
- 2016
- English.
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In: The Journal of antimicrobial chemotherapy. - : Oxford University Press (OUP). - 1460-2091 .- 0305-7453. ; 71:9, s. 2397-2404
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https://academic.oup...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- The 5th European Conference on Infections in Leukaemia (ECIL-5) meeting aimed to establish evidence-based recommendations for the prophylaxis of Pneumocystis jirovecii pneumonia (PCP) in non-HIV-infected patients with an underlying haematological condition, including allogeneic HSCT recipients. Recommendations were based on the grading system of the IDSA. Trimethoprim/sulfamethoxazole given 2–3 times weekly is the drug of choice for the primary prophylaxis of PCP in adults (A-II) and children (A-I) and should be given during the entire period at risk. Recent data indicate that children may benefit equally from a once-weekly regimen (B-II). All other drugs, including pentamidine, atovaquone and dapsone, are considered second-line alternatives when trimethoprim/sulfamethoxazole is poorly tolerated or contraindicated. The main indications of PCP prophylaxis are ALL, allogeneic HSCT, treatment with alemtuzumab, fludarabine/cyclophosphamide/rituximab combinations, >4 weeks of treatment with corticosteroids and well-defined primary immune deficiencies in children. Additional indications are proposed depending on the treatment regimen.
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- art (subject category)
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- By the author/editor
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Maertens, J
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Cesaro, S
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Maschmeyer, G
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Einsele, H
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Donnelly, JP
-
Alanio, A
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show more...
-
Hauser, PM
-
Lagrou, K
-
Melchers, WJG
-
Helweg-Larsen, J
-
Matos, O
-
Bretagne, S
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Cordonnier, C
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show less...
- Articles in the publication
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The Journal of a ...
- By the university
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Karolinska Institutet