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- Ferreira, DKarolinska Institutet (author)
Electroencephalography Is a Good Complement to Currently Established Dementia Biomarkers
- Article/chapterEnglish2016
Publisher, publication year, extent ...
- 2016-09-06
- S. Karger AG,2016
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- LIBRIS-ID:oai:prod.swepub.kib.ki.se:134394908
- http://kipublications.ki.se/Default.aspx?queryparsed=id:134394908URI
- https://doi.org/10.1159/000448394DOI
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- Language:English
- Summary in:English
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- <b><i>Background/Aims:</i></b> Dementia biomarkers that are accessible and easily applicable in nonspecialized clinical settings are urgently needed. Quantitative electroencephalography (qEEG) is a good candidate, and the statistical pattern recognition (SPR) method has recently provided promising results. We tested the diagnostic value of qEEG-SPR in comparison to cognition, structural imaging, and cerebrospinal fluid (CSF) biomarkers. <b><i>Methods:</i></b> A total of 511 individuals were recruited from the multicenter NORD EEG study [141 healthy controls, 64 subjective cognitive decline, 124 mild cognitive impairment, 135 Alzheimer's disease (AD), 15 dementia with Lewy bodies/Parkinson's disease with dementia (DLB/PDD), 32 other dementias]. The EEG data were recorded in a standardized way. Structural imaging data were visually rated using scales of atrophy in the medial temporal, frontal, and posterior cortex. <b><i>Results:</i></b> qEEG-SPR outperformed structural imaging, cognition, and CSF biomarkers in DLB/PDD diagnosis, outperformed structural imaging in AD diagnosis, and improved the differential diagnosis of AD. In addition, qEEG-SPR allowed differentiation of two clinically different AD subtypes. <b><i>Conclusion:</i></b> Adding qEEG to the diagnostic workup substantially increases the detection of AD pathology even in pre-dementia stages and improves differential diagnosis. EEG could serve as a good complement to currently established dementia biomarkers since it is cheap, noninvasive, and extensively applied outside academic centers.
Added entries (persons, corporate bodies, meetings, titles ...)
- Jelic, VKarolinska Institutet (author)
- Cavallin, LKarolinska Institutet (author)
- Oeksengaard, AR (author)
- Snaedal, J (author)
- Hogh, P (author)
- Andersen, BB (author)
- Naik, M (author)
- Engedal, K (author)
- Westman, EKarolinska Institutet (author)
- Wahlund, LOKarolinska Institutet (author)
- Karolinska Institutet (creator_code:org_t)
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- In:Dementia and geriatric cognitive disorders: S. Karger AG42:1-2, s. 80-921421-98241420-8008
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- Naik, M
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