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Electroencephalogra...
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Ferreira, DKarolinska Institutet
(author)
Electroencephalography Is a Good Complement to Currently Established Dementia Biomarkers
- Article/chapterEnglish2016
Publisher, publication year, extent ...
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2016-09-06
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S. Karger AG,2016
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:134394908
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http://kipublications.ki.se/Default.aspx?queryparsed=id:134394908URI
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https://doi.org/10.1159/000448394DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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<b><i>Background/Aims:</i></b> Dementia biomarkers that are accessible and easily applicable in nonspecialized clinical settings are urgently needed. Quantitative electroencephalography (qEEG) is a good candidate, and the statistical pattern recognition (SPR) method has recently provided promising results. We tested the diagnostic value of qEEG-SPR in comparison to cognition, structural imaging, and cerebrospinal fluid (CSF) biomarkers. <b><i>Methods:</i></b> A total of 511 individuals were recruited from the multicenter NORD EEG study [141 healthy controls, 64 subjective cognitive decline, 124 mild cognitive impairment, 135 Alzheimer's disease (AD), 15 dementia with Lewy bodies/Parkinson's disease with dementia (DLB/PDD), 32 other dementias]. The EEG data were recorded in a standardized way. Structural imaging data were visually rated using scales of atrophy in the medial temporal, frontal, and posterior cortex. <b><i>Results:</i></b> qEEG-SPR outperformed structural imaging, cognition, and CSF biomarkers in DLB/PDD diagnosis, outperformed structural imaging in AD diagnosis, and improved the differential diagnosis of AD. In addition, qEEG-SPR allowed differentiation of two clinically different AD subtypes. <b><i>Conclusion:</i></b> Adding qEEG to the diagnostic workup substantially increases the detection of AD pathology even in pre-dementia stages and improves differential diagnosis. EEG could serve as a good complement to currently established dementia biomarkers since it is cheap, noninvasive, and extensively applied outside academic centers.
Added entries (persons, corporate bodies, meetings, titles ...)
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Jelic, VKarolinska Institutet
(author)
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Cavallin, LKarolinska Institutet
(author)
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Oeksengaard, AR
(author)
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Snaedal, J
(author)
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Hogh, P
(author)
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Andersen, BB
(author)
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Naik, M
(author)
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Engedal, K
(author)
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Westman, EKarolinska Institutet
(author)
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Wahlund, LOKarolinska Institutet
(author)
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Karolinska Institutet
(creator_code:org_t)
Related titles
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In:Dementia and geriatric cognitive disorders: S. Karger AG42:1-2, s. 80-921421-98241420-8008
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Ferreira, D
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Jelic, V
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Cavallin, L
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Oeksengaard, AR
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Snaedal, J
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Hogh, P
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Andersen, BB
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Naik, M
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Engedal, K
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Westman, E
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Wahlund, LO
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Dementia and ger ...
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Karolinska Institutet