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Transcriptional Dyn...
Transcriptional Dynamics During Human Adipogenesis and Its Link to Adipose Morphology and Distribution
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- Ehrlund, A (author)
- Karolinska Institutet,Karolinska Inst, Dept Med, Stockholm, Sweden
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- Mejhert, N (author)
- Karolinska Institutet,Karolinska Inst, Dept Med, Stockholm, Sweden
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- Bjork, C (author)
- Karolinska Inst, Dept Med, Stockholm, Sweden
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- Andersson, R (author)
- Univ Copenhagen, Dept Biol, Bioinformat Ctr, Copenhagen, Denmark;Univ Copenhagen, Biotech Res & Innovat Ctr, Copenhagen, Denmark
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- Kulyte, A (author)
- Karolinska Institutet,Karolinska Inst, Dept Med, Stockholm, Sweden
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- Astrom, G (author)
- Karolinska Institutet,Karolinska Inst, Dept Med, Stockholm, Sweden
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- Itoh, M (author)
- RIKEN Prevent Med & Diag Innovat Program, Wako, Saitama, Japan;RIKEN Ctr Life Sci Technol, Div Genom Technol, Yokohama, Kanagawa, Japan;RIKEN Omics Sci Ctr, Yokohama, Kanagawa, Japan
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- Kawaji, H (author)
- RIKEN Prevent Med & Diag Innovat Program, Wako, Saitama, Japan;RIKEN Ctr Life Sci Technol, Div Genom Technol, Yokohama, Kanagawa, Japan;RIKEN Omics Sci Ctr, Yokohama, Kanagawa, Japan
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- Lassmann, T (author)
- Telethon Kids Inst, Perth, WA, Australia;Univ Western Australia, Perth, WA, Australia;RIKEN Ctr Life Sci Technol, Div Genom Technol, Yokohama, Kanagawa, Japan;RIKEN Omics Sci Ctr, Yokohama, Kanagawa, Japan
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- Daub, CO (author)
- Karolinska Institutet,Karolinska Inst, Dept Biosci & Nutr, Stockholm, Sweden;RIKEN Ctr Life Sci Technol, Div Genom Technol, Yokohama, Kanagawa, Japan;Karolinska Inst, Sci Life Lab, Stockholm, Sweden
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- Carninci, P (author)
- RIKEN Ctr Life Sci Technol, Div Genom Technol, Yokohama, Kanagawa, Japan;RIKEN Omics Sci Ctr, Yokohama, Kanagawa, Japan
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- Forrest, ARR (author)
- RIKEN Ctr Life Sci Technol, Div Genom Technol, Yokohama, Kanagawa, Japan;RIKEN Omics Sci Ctr, Yokohama, Kanagawa, Japan
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- Hayashizaki, Y (author)
- RIKEN Prevent Med & Diag Innovat Program, Wako, Saitama, Japan;RIKEN Omics Sci Ctr, Yokohama, Kanagawa, Japan
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- Sandelin, A (author)
- Univ Copenhagen, Dept Biol, Bioinformat Ctr, Copenhagen, Denmark;Univ Copenhagen, Biotech Res & Innovat Ctr, Copenhagen, Denmark
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- Ingelsson, Erik, 1975- (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi,Stanford Univ, Dept Med, Sch Med, Div Cardiovasc Med, Stanford, CA 94305 USA
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- Ryden, M (author)
- Karolinska Institutet,Karolinska Inst, Dept Med, Stockholm, Sweden
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- Laurencikiene, J (author)
- Karolinska Institutet,Karolinska Inst, Dept Med, Stockholm, Sweden
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- Arner, P (author)
- Karolinska Institutet,Karolinska Inst, Dept Med, Stockholm, Sweden
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- Arner, E (author)
- RIKEN Ctr Life Sci Technol, Div Genom Technol, Yokohama, Kanagawa, Japan;Karolinska Inst, Dept Med, Stockholm, Sweden;RIKEN Omics Sci Ctr, Yokohama, Kanagawa, Japan
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(creator_code:org_t)
- 2016-11-01
- 2017
- English.
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In: Diabetes. - : American Diabetes Association. - 1939-327X .- 0012-1797. ; 66:1, s. 218-230
- Related links:
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https://diabetes.dia...
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http://kipublication...
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https://doi.org/10.2...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- White adipose tissue (WAT) can develop into several phenotypes with different pathophysiological impact on type 2 diabetes. To better understand the adipogenic process, the transcriptional events that occur during in vitro differentiation of human adipocytes were investigated and the findings linked to WAT phenotypes. Single-molecule transcriptional profiling provided a detailed map of the expressional changes of genes, enhancers, and long noncoding RNAs, where different types of transcripts share common dynamics during differentiation. Common signatures include early downregulated, transient, and late induced transcripts, all of which are linked to distinct developmental processes during adipogenesis. Enhancers expressed during adipogenesis overlap significantly with genetic variants associated with WAT distribution. Transiently expressed and late induced genes are associated with hypertrophic WAT (few but large fat cells), a phenotype closely linked to insulin resistance and type 2 diabetes. Transcription factors that are expressed early or transiently affect differentiation and adipocyte function and are controlled by several well-known upstream regulators such as glucocorticosteroids, insulin, cAMP, and thyroid hormones. Taken together, our results suggest a complex but highly coordinated regulation of adipogenesis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Diabetes
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- By the author/editor
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Ehrlund, A
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Mejhert, N
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Bjork, C
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Andersson, R
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Kulyte, A
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Astrom, G
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Itoh, M
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Kawaji, H
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Lassmann, T
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Daub, CO
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Carninci, P
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Forrest, ARR
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Hayashizaki, Y
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Sandelin, A
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Ingelsson, Erik, ...
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Ryden, M
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Laurencikiene, J
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Arner, P
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Arner, E
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Physiology
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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Diabetes
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Karolinska Institutet
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Uppsala University