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A framework for rem...
A framework for remission in SLE: consensus findings from a large international task force on definitions of remission in SLE (DORIS)
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- van Vollenhoven, R (author)
- Karolinska Institutet
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Voskuyl, A (author)
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Bertsias, G (author)
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Aranow, C (author)
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Aringer, M (author)
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Arnaud, L (author)
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Askanase, A (author)
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Balazova, P (author)
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Bonfa, E (author)
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Bootsma, H (author)
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Boumpas, D (author)
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Bruce, I (author)
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Cervera, R (author)
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Clarke, A (author)
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Coney, C (author)
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Costedoat-Chalumeau, N (author)
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Czirjak, L (author)
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Derksen, R (author)
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Doria, A (author)
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Dorner, T (author)
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Fischer-Betz, R (author)
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Fritsch-Stork, R (author)
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Gordon, C (author)
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Graninger, W (author)
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Gyori, N (author)
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Houssiau, F (author)
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Isenberg, D (author)
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Jacobsen, S (author)
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Jayne, D (author)
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Kuhn, A (author)
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Le Guern, V (author)
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Lerstrom, K (author)
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Levy, R (author)
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Machado-Ribeiro, F (author)
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Mariette, X (author)
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Missaykeh, J (author)
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Morand, E (author)
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Mosca, M (author)
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Inanc, M (author)
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Navarra, S (author)
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Neumann, I (author)
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Olesinska, M (author)
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Petri, M (author)
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Rahman, A (author)
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Rekvig, OP (author)
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Rovensky, J (author)
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Shoenfeld, Y (author)
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Smolen, J (author)
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Tincani, A (author)
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Urowitz, M (author)
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van Leeuw, B (author)
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Vasconcelos, C (author)
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Voss, A (author)
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Werth, VP (author)
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Zakharova, H (author)
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Zoma, A (author)
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Schneider, M (author)
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Ward, M (author)
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(creator_code:org_t)
- 2016-11-24
- 2017
- English.
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In: Annals of the rheumatic diseases. - : BMJ. - 1468-2060 .- 0003-4967. ; 76:3, s. 554-561
- Related links:
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http://diposit.ub.ed...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- Treat-to-target recommendations have identified ‘remission’ as a target in systemic lupus erythematosus (SLE), but recognise that there is no universally accepted definition for this. Therefore, we initiated a process to achieve consensus on potential definitions for remission in SLE.MethodsAn international task force of 60 specialists and patient representatives participated in preparatory exercises, a face-to-face meeting and follow-up electronic voting. The level for agreement was set at 90%.ResultsThe task force agreed on eight key statements regarding remission in SLE and three principles to guide the further development of remission definitions:1. Definitions of remission will be worded as follows: remission in SLE is a durable state characterised by …………………. (reference to symptoms, signs, routine labs).2. For defining remission, a validated index must be used, for example, clinical systemic lupus erythematosus disease activity index (SLEDAI)=0, British Isles lupus assessment group (BILAG) 2004 D/E only, clinical European consensus lupus outcome measure (ECLAM)=0; with routine laboratory assessments included, and supplemented with physician's global assessment.3. Distinction is made between remission off and on therapy: remission off therapy requires the patient to be on no other treatment for SLE than maintenance antimalarials; and remission on therapy allows patients to be on stable maintenance antimalarials, low-dose corticosteroids (prednisone ≤5 mg/day), maintenance immunosuppressives and/or maintenance biologics.The task force also agreed that the most appropriate outcomes (dependent variables) for testing the prognostic value (construct validity) of potential remission definitions are: death, damage, flares and measures of health-related quality of life.ConclusionsThe work of this international task force provides a framework for testing different definitions of remission against long-term outcomes.
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- ref (subject category)
- art (subject category)
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- By the author/editor
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van Vollenhoven, ...
-
Voskuyl, A
-
Bertsias, G
-
Aranow, C
-
Aringer, M
-
Arnaud, L
-
show more...
-
Askanase, A
-
Balazova, P
-
Bonfa, E
-
Bootsma, H
-
Boumpas, D
-
Bruce, I
-
Cervera, R
-
Clarke, A
-
Coney, C
-
Costedoat-Chalum ...
-
Czirjak, L
-
Derksen, R
-
Doria, A
-
Dorner, T
-
Fischer-Betz, R
-
Fritsch-Stork, R
-
Gordon, C
-
Graninger, W
-
Gyori, N
-
Houssiau, F
-
Isenberg, D
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Jacobsen, S
-
Jayne, D
-
Kuhn, A
-
Le Guern, V
-
Lerstrom, K
-
Levy, R
-
Machado-Ribeiro, ...
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Mariette, X
-
Missaykeh, J
-
Morand, E
-
Mosca, M
-
Inanc, M
-
Navarra, S
-
Neumann, I
-
Olesinska, M
-
Petri, M
-
Rahman, A
-
Rekvig, OP
-
Rovensky, J
-
Shoenfeld, Y
-
Smolen, J
-
Tincani, A
-
Urowitz, M
-
van Leeuw, B
-
Vasconcelos, C
-
Voss, A
-
Werth, VP
-
Zakharova, H
-
Zoma, A
-
Schneider, M
-
Ward, M
-
show less...
- Articles in the publication
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Annals of the rh ...
- By the university
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Karolinska Institutet