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Polyphosphate nanoparticles on the platelet surface trigger contact system activation
- Verhoef, JJF (author)
- Barendrecht, AD (author)
- Nickel, KF (author)
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- Dijkxhoorn, K (author)
- Labberton, L (author)
- McCarty, OJT (author)
- Schiffelers, R (author)
- Heijnen, HF (author)
- Hendrickx, AP (author)
- Schellekens, H (author)
- Fens, MH (author)
- de Maat, S (author)
- Maas, C (author)
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- (creator_code:org_t)
- American Society of Hematology, 2017
- 2017
- English.
- In: Blood. - : American Society of Hematology. - 1528-0020 .- 0006-4971. ; 129:12, s. 1707-1717
- Journal article (peer-reviewed)
Abstract
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- Activated platelets expose insoluble membrane-associated polyphosphate nanoparticles that are complexed with divalent metal ions. Platelet polyphosphate nanoparticles, but not soluble polyphosphate polymers, activate the contact system.
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- art (subject category)
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- Verhoef, JJF
- Barendrecht, AD
- Nickel, KF
- Dijkxhoorn, K
- Kenne, E
- Labberton, L
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- McCarty, OJT
- Schiffelers, R
- Heijnen, HF
- Hendrickx, AP
- Schellekens, H
- Fens, MH
- de Maat, S
- Renne, T
- Maas, C
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- Articles in the publication
- Blood
- By the university
- Karolinska Institutet
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