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  • Ferreira, DKarolinska Institutet (author)

Distinct subtypes of Alzheimer's disease based on patterns of brain atrophy: longitudinal trajectories and clinical applications

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • 2017-04-18
  • Springer Science and Business Media LLC,2017

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  • LIBRIS-ID:oai:prod.swepub.kib.ki.se:135742861
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:135742861URI
  • https://doi.org/10.1038/srep46263DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Atrophy patterns on MRI can reliably predict three neuropathological subtypes of Alzheimer’s disease (AD): typical, limbic-predominant, or hippocampal-sparing. A method to enable their investigation in the clinical routine is still lacking. We aimed to (1) validate the combined use of visual rating scales for identification of AD subtypes; (2) characterise these subtypes at baseline and over two years; and (3) investigate how atrophy patterns and non-memory cognitive domains contribute to memory impairment. AD patients were classified as either typical AD (n = 100), limbic-predominant (n = 33), or hippocampal-sparing (n = 35) by using the Scheltens’ scale for medial temporal lobe atrophy (MTA), the Koedam’s scale for posterior atrophy (PA), and the Pasquier’s global cortical atrophy scale for frontal atrophy (GCA-F). A fourth group with no atrophy was also identified (n = 30). 230 healthy controls were also included. There was great overlap among subtypes in demographic, clinical, and cognitive variables. Memory performance was more dependent on non-memory cognitive functions in hippocampal-sparing and the no atrophy group. Hippocampal-sparing and the no atrophy group showed less aggressive disease progression. Visual rating scales can be used to identify distinct AD subtypes. Recognizing AD heterogeneity is important and visual rating scales may facilitate investigation of AD heterogeneity in clinical routine.

Added entries (persons, corporate bodies, meetings, titles ...)

  • Verhagen, C (author)
  • Hernandez-Cabrera, JA (author)
  • Cavallin, LKarolinska Institutet (author)
  • Guo, CJ (author)
  • Ekman, UKarolinska Institutet (author)
  • Muehlboeck, JSKarolinska Institutet (author)
  • Simmons, A (author)
  • Barroso, J (author)
  • Wahlund, LOKarolinska Institutet (author)
  • Westman, EKarolinska Institutet (author)
  • Karolinska Institutet (creator_code:org_t)

Related titles

  • In:Scientific reports: Springer Science and Business Media LLC7, s. 46263-2045-2322

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