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Skin microvascular ...
Skin microvascular function in patients with type 1 diabetes: An observational study from the onset of diabetes
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- Santesson, P (author)
- Karolinska Institutet
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Lins, PE (author)
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Kalani, M (author)
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Adamson, U (author)
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Lelic, I (author)
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von Wendt, G (author)
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Fagrell, B (author)
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Jorneskog, G (author)
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(creator_code:org_t)
- 2017-03-01
- 2017
- English.
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In: Diabetes & vascular disease research. - : SAGE Publications. - 1752-8984 .- 1479-1641. ; 14:3, s. 191-199
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- The development of disturbances in skin microcirculation in type 1 diabetes is not well characterised. We assessed skin microcirculation longitudinally from the onset of diabetes up to 29 years of duration to investigate when such disturbances start. Material and methods: Seventeen adult patients with type 1 diabetes participated. Skin microvascular function in digit IV of the left hand was investigated by laser Doppler fluxmetry (LDF, arbitrary units [AU]). LDF was carried out at rest and following one-min arterial occlusion. Time to peak LDF (s) and percentage increase of LDF (post-occlusive reactive hyperaemia, PRH%) were determined. Retinopathy was assessed from fundus photographs or ophthalmoscopic recordings. Results: Skin microvascular function remained normal during the first five years. Compared with baseline and a non-diabetic reference group, time to peak LDF was prolonged after 7–9 years of diabetes ( p < 0.01). PRH% was lower than in the reference group after 7–9 years ( p < 0.01), and lower than baseline after 24–29 years of diabetes ( p < 0.05). All but one patient developed retinopathy and the first signs were found after 10 years of diabetes. Conclusions: Functional disturbances in total skin microcirculation were observed after seven years in patients with type 1 diabetes and preceded diabetic complications such as retinopathy.
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- art (subject category)
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