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Impact of fat mass ...
Impact of fat mass and distribution on lipid turnover in human adipose tissue
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- Spalding, KL (author)
- Karolinska Institutet,Karolinska Inst, Dept Mol & Cell Biol, SE-17177 Stockholm, Sweden.;Karolinska Inst, Metab Unit, SE-17176 Stockholm, Sweden.;Karolinska Inst, Karolinska Univ Hosp, KI AZ Integrated Cardio Metab Ctr, Dept Med, SE-17176 Stockholm, Sweden.
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- Bernard, S (author)
- Univ Lyon, Inst Camille Jordan, F-69622 Villeurbanne, France.
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- Naslund, E (author)
- Karolinska Institutet,Karolinska Inst, Danderyd Hosp, Dept Clin Sci, SE-18288 Stockholm, Sweden.
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- Salehpour, Mehran, 1960- (author)
- Uppsala universitet,Tillämpad kärnfysik
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- Possnert, Göran, 1951- (author)
- Uppsala universitet,Tillämpad kärnfysik
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- Appelsved, L (author)
- Karolinska Institutet,Karolinska Inst, Dept Mol & Cell Biol, SE-17177 Stockholm, Sweden.
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- Fu, KY (author)
- Karolinska Institutet,Karolinska Inst, Dept Mol & Cell Biol, SE-17177 Stockholm, Sweden.
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- Alkass, K (author)
- Karolinska Institutet,Karolinska Inst, Dept Mol & Cell Biol, SE-17177 Stockholm, Sweden.
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- Druid, H (author)
- Karolinska Institutet,Karolinska Inst, Dept Oncol Pathol, SE-17177 Stockholm, Sweden.;Natl Board Forens Med, Dept Forens Med, SE-11120 Stockholm, Sweden.
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- Thorell, A (author)
- Karolinska Institutet,Karolinska Inst, Danderyd Hosp, Dept Clin Sci, SE-18288 Stockholm, Sweden.;Karolinska Inst, Ersta Hosp, Dept Surg, SE-11691 Stockholm, Sweden.
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- Ryden, M (author)
- Karolinska Institutet,Karolinska Inst, Karolinska Univ Hosp, Dept Med, SE-14186 Stockholm, Sweden.
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- Arner, P (author)
- Karolinska Institutet,Karolinska Inst, Karolinska Univ Hosp, Dept Med, SE-14186 Stockholm, Sweden.
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Karolinska Institutet Karolinska Inst, Dept Mol & Cell Biol, SE-17177 Stockholm, Sweden;Karolinska Inst, Metab Unit, SE-17176 Stockholm, Sweden.;Karolinska Inst, Karolinska Univ Hosp, KI AZ Integrated Cardio Metab Ctr, Dept Med, SE-17176 Stockholm, Sweden. (creator_code:org_t)
- 2017-05-23
- 2017
- English.
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In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8, s. 15253-
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Abstract
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- Differences in white adipose tissue (WAT) lipid turnover between the visceral (vWAT) and subcutaneous (sWAT) depots may cause metabolic complications in obesity. Here we compare triglyceride age and, thereby, triglyceride turnover in vWAT and sWAT biopsies from 346 individuals and find that subcutaneous triglyceride age and storage capacity are increased in overweight or obese individuals. Visceral triglyceride age is only increased in excessively obese individuals and associated with a lower lipid removal capacity. Thus, although triglyceride storage capacity in sWAT is higher than in vWAT, the former plateaus at substantially lower levels of excess WAT mass than vWAT. In individuals with central or visceral obesity, lipid turnover is selectively increased in vWAT. Obese individuals classified as ‘metabolically unhealthy’ (according to ATPIII criteria) who have small subcutaneous adipocytes exhibit reduced triglyceride turnover. We conclude that excess WAT results in depot-specific differences in lipid turnover and increased turnover in vWAT and/or decreased turnover in sWAT may result in metabolic complications of overweight or obesity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Spalding, KL
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Bernard, S
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Naslund, E
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Salehpour, Mehra ...
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Possnert, Göran, ...
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Appelsved, L
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show more...
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Fu, KY
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Alkass, K
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Druid, H
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Thorell, A
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Ryden, M
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Arner, P
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
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and Medical Biotechn ...
- Articles in the publication
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Nature communica ...
- By the university
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Karolinska Institutet
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Uppsala University