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Effectiveness and s...
Effectiveness and safety of bedaquiline-containing regimens in the treatment of MDR- and XDR-TB: a multicentre study
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Borisov, SE (author)
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Dheda, K (author)
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Enwerem, M (author)
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Leyet, RR (author)
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D'Ambrosio, L (author)
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Centis, R (author)
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Sotgiu, G (author)
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Tiberi, S (author)
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Alffenaar, JW (author)
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Maryandyshev, A (author)
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Belilovski, E (author)
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Ganatra, S (author)
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Skrahina, A (author)
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Akkerman, O (author)
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Aleksa, A (author)
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Amale, R (author)
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Artsukevich, J (author)
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- Bruchfeld, J (author)
- Karolinska Institutet
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Caminero, JA (author)
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Martinez, IC (author)
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Codecasa, L (author)
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Dalcolmo, M (author)
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Denholm, J (author)
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Douglas, P (author)
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Duarte, R (author)
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Esmail, A (author)
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Fadul, M (author)
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Filippov, A (author)
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- Forsman, LD (author)
- Karolinska Institutet
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Gaga, M (author)
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Garcia-Fuertes, JA (author)
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Garcia-Garcia, JM (author)
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Gualano, G (author)
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Jonsson, J (author)
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Kunst, H (author)
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Lau, JS (author)
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Mastrapa, BL (author)
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Troya, JLT (author)
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Manga, S (author)
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Manika, K (author)
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Montaner, PG (author)
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Mullerpattan, J (author)
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Oelofse, S (author)
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Ortelli, M (author)
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Palmero, DJ (author)
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Palmieri, F (author)
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Papalia, A (author)
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Papavasileiou, A (author)
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Payen, MC (author)
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Pontali, E (author)
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Cordeiro, CR (author)
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Saderi, L (author)
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Sadutshang, TD (author)
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Sanukevich, T (author)
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Solodovnikova, V (author)
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Spanevello, A (author)
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Topgyal, S (author)
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Toscanini, F (author)
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Tramontana, AR (author)
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Udwadia, ZF (author)
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Viggiani, P (author)
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White, V (author)
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Zumla, A (author)
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Migliori, GB (author)
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(creator_code:org_t)
- 2017-05-21
- 2017
- English.
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In: The European respiratory journal. - : European Respiratory Society (ERS). - 1399-3003 .- 0903-1936. ; 49:5
- Related links:
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https://erj.ersjourn...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- Large studies on bedaquiline used to treat multidrug-resistant (MDR-) and extensively drug-resistant tuberculosis (XDR-TB) are lacking. This study aimed to evaluate the safety and effectiveness of bedaquiline-containing regimens in a large, retrospective, observational study conducted in 25 centres and 15 countries in five continents.428 culture-confirmed MDR-TB cases were analysed (61.5% male; 22.1% HIV-positive, 45.6% XDR-TB). MDR-TB cases were admitted to hospital for a median (interquartile range (IQR)) 179 (92–280) days and exposed to bedaquiline for 168 (86–180) days. Treatment regimens included, among others, linezolid, moxifloxacin, clofazimine and carbapenems (82.0%, 58.4%, 52.6% and 15.3% of cases, respectively).Sputum smear and culture conversion rates in MDR-TB cases were 63.6% and 30.1%, respectively at 30 days, 81.1% and 56.7%, respectively at 60 days; 85.5% and 80.5%, respectively at 90 days and 88.7% and 91.2%, respectively at the end of treatment. The median (IQR) time to smear and culture conversion was 34 (30–60) days and 60 (33–90) days. Out of 247 culture-confirmed MDR-TB cases completing treatment, 71.3% achieved success (62.4% cured; 8.9% completed treatment), 13.4% died, 7.3% defaulted and 7.7% failed. Bedaquiline was interrupted due to adverse events in 5.8% of cases. A single case died, having electrocardiographic abnormalities that were probably non-bedaquiline related.Bedaquiline-containing regimens achieved high conversion and success rates under different nonexperimental conditions.
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Borisov, SE
-
Dheda, K
-
Enwerem, M
-
Leyet, RR
-
D'Ambrosio, L
-
Centis, R
-
show more...
-
Sotgiu, G
-
Tiberi, S
-
Alffenaar, JW
-
Maryandyshev, A
-
Belilovski, E
-
Ganatra, S
-
Skrahina, A
-
Akkerman, O
-
Aleksa, A
-
Amale, R
-
Artsukevich, J
-
Bruchfeld, J
-
Caminero, JA
-
Martinez, IC
-
Codecasa, L
-
Dalcolmo, M
-
Denholm, J
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Douglas, P
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Duarte, R
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Esmail, A
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Fadul, M
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Filippov, A
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Forsman, LD
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Gaga, M
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Garcia-Fuertes, ...
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Garcia-Garcia, J ...
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Gualano, G
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Jonsson, J
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Kunst, H
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Lau, JS
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Mastrapa, BL
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Troya, JLT
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Manga, S
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Manika, K
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Montaner, PG
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Mullerpattan, J
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Oelofse, S
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Ortelli, M
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Palmero, DJ
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Palmieri, F
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Papalia, A
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Papavasileiou, A
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Payen, MC
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Pontali, E
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Cordeiro, CR
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Saderi, L
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Sadutshang, TD
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Sanukevich, T
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Solodovnikova, V
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Spanevello, A
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Topgyal, S
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Toscanini, F
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Tramontana, AR
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Udwadia, ZF
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Viggiani, P
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White, V
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Zumla, A
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Migliori, GB
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show less...
- Articles in the publication
-
The European res ...
- By the university
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Karolinska Institutet