Search: onr:"swepub:oai:prod.swepub.kib.ki.se:135882176" >
Effectiveness and s...
Effectiveness and safety of bedaquiline-containing regimens in the treatment of MDR- and XDR-TB: a multicentre study
- Article/chapterEnglish2017
Publisher, publication year, extent ...
-
2017-05-21
-
European Respiratory Society (ERS),2017
Numbers
-
LIBRIS-ID:oai:prod.swepub.kib.ki.se:135882176
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:135882176URI
-
https://doi.org/10.1183/13993003.00387-2017DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Large studies on bedaquiline used to treat multidrug-resistant (MDR-) and extensively drug-resistant tuberculosis (XDR-TB) are lacking. This study aimed to evaluate the safety and effectiveness of bedaquiline-containing regimens in a large, retrospective, observational study conducted in 25 centres and 15 countries in five continents.428 culture-confirmed MDR-TB cases were analysed (61.5% male; 22.1% HIV-positive, 45.6% XDR-TB). MDR-TB cases were admitted to hospital for a median (interquartile range (IQR)) 179 (92–280) days and exposed to bedaquiline for 168 (86–180) days. Treatment regimens included, among others, linezolid, moxifloxacin, clofazimine and carbapenems (82.0%, 58.4%, 52.6% and 15.3% of cases, respectively).Sputum smear and culture conversion rates in MDR-TB cases were 63.6% and 30.1%, respectively at 30 days, 81.1% and 56.7%, respectively at 60 days; 85.5% and 80.5%, respectively at 90 days and 88.7% and 91.2%, respectively at the end of treatment. The median (IQR) time to smear and culture conversion was 34 (30–60) days and 60 (33–90) days. Out of 247 culture-confirmed MDR-TB cases completing treatment, 71.3% achieved success (62.4% cured; 8.9% completed treatment), 13.4% died, 7.3% defaulted and 7.7% failed. Bedaquiline was interrupted due to adverse events in 5.8% of cases. A single case died, having electrocardiographic abnormalities that were probably non-bedaquiline related.Bedaquiline-containing regimens achieved high conversion and success rates under different nonexperimental conditions.
Added entries (persons, corporate bodies, meetings, titles ...)
-
Dheda, K
(author)
-
Enwerem, M
(author)
-
Leyet, RR
(author)
-
D'Ambrosio, L
(author)
-
Centis, R
(author)
-
Sotgiu, G
(author)
-
Tiberi, S
(author)
-
Alffenaar, JW
(author)
-
Maryandyshev, A
(author)
-
Belilovski, E
(author)
-
Ganatra, S
(author)
-
Skrahina, A
(author)
-
Akkerman, O
(author)
-
Aleksa, A
(author)
-
Amale, R
(author)
-
Artsukevich, J
(author)
-
Bruchfeld, JKarolinska Institutet
(author)
-
Caminero, JA
(author)
-
Martinez, IC
(author)
-
Codecasa, L
(author)
-
Dalcolmo, M
(author)
-
Denholm, J
(author)
-
Douglas, P
(author)
-
Duarte, R
(author)
-
Esmail, A
(author)
-
Fadul, M
(author)
-
Filippov, A
(author)
-
Forsman, LDKarolinska Institutet
(author)
-
Gaga, M
(author)
-
Garcia-Fuertes, JA
(author)
-
Garcia-Garcia, JM
(author)
-
Gualano, G
(author)
-
Jonsson, J
(author)
-
Kunst, H
(author)
-
Lau, JS
(author)
-
Mastrapa, BL
(author)
-
Troya, JLT
(author)
-
Manga, S
(author)
-
Manika, K
(author)
-
Montaner, PG
(author)
-
Mullerpattan, J
(author)
-
Oelofse, S
(author)
-
Ortelli, M
(author)
-
Palmero, DJ
(author)
-
Palmieri, F
(author)
-
Papalia, A
(author)
-
Papavasileiou, A
(author)
-
Payen, MC
(author)
-
Pontali, E
(author)
-
Cordeiro, CR
(author)
-
Saderi, L
(author)
-
Sadutshang, TD
(author)
-
Sanukevich, T
(author)
-
Solodovnikova, V
(author)
-
Spanevello, A
(author)
-
Topgyal, S
(author)
-
Toscanini, F
(author)
-
Tramontana, AR
(author)
-
Udwadia, ZF
(author)
-
Viggiani, P
(author)
-
White, V
(author)
-
Zumla, A
(author)
-
Migliori, GB
(author)
-
Karolinska Institutet
(creator_code:org_t)
Related titles
-
In:The European respiratory journal: European Respiratory Society (ERS)49:51399-30030903-1936
Internet link
Find in a library
To the university's database
- By the author/editor
-
Borisov, SE
-
Dheda, K
-
Enwerem, M
-
Leyet, RR
-
D'Ambrosio, L
-
Centis, R
-
show more...
-
Sotgiu, G
-
Tiberi, S
-
Alffenaar, JW
-
Maryandyshev, A
-
Belilovski, E
-
Ganatra, S
-
Skrahina, A
-
Akkerman, O
-
Aleksa, A
-
Amale, R
-
Artsukevich, J
-
Bruchfeld, J
-
Caminero, JA
-
Martinez, IC
-
Codecasa, L
-
Dalcolmo, M
-
Denholm, J
-
Douglas, P
-
Duarte, R
-
Esmail, A
-
Fadul, M
-
Filippov, A
-
Forsman, LD
-
Gaga, M
-
Garcia-Fuertes, ...
-
Garcia-Garcia, J ...
-
Gualano, G
-
Jonsson, J
-
Kunst, H
-
Lau, JS
-
Mastrapa, BL
-
Troya, JLT
-
Manga, S
-
Manika, K
-
Montaner, PG
-
Mullerpattan, J
-
Oelofse, S
-
Ortelli, M
-
Palmero, DJ
-
Palmieri, F
-
Papalia, A
-
Papavasileiou, A
-
Payen, MC
-
Pontali, E
-
Cordeiro, CR
-
Saderi, L
-
Sadutshang, TD
-
Sanukevich, T
-
Solodovnikova, V
-
Spanevello, A
-
Topgyal, S
-
Toscanini, F
-
Tramontana, AR
-
Udwadia, ZF
-
Viggiani, P
-
White, V
-
Zumla, A
-
Migliori, GB
-
show less...
- Articles in the publication
-
The European res ...
- By the university
-
Karolinska Institutet