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Incidence and preva...
Incidence and prevalence of psoriatic arthritis in Denmark: a nationwide register linkage study
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Egeberg, A (author)
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Kristensen, LE (author)
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Thyssen, JP (author)
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Gislason, GH (author)
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Gottlieb, AB (author)
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Coates, LC (author)
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Jullien, D (author)
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Gisondi, P (author)
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Gladman, DD (author)
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Skov, L (author)
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- Mallbris, L (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2017-05-08
- 2017
- English.
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In: Annals of the rheumatic diseases. - : BMJ. - 1468-2060 .- 0003-4967. ; 76:9, s. 1591-1597
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https://ora.ox.ac.uk...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- To examine the incidence and temporal trends of psoriatic arthritis (PsA) in the general population in Denmark.MethodsUsing nationwide registry data, we estimated the number of patients with incident PsA within each 1-year period between 1997 and 2011 and calculated the rate of PsA cases within gender and age subgroups. Incidence rates were presented per 100 000 person-years.ResultsThere was a female predominance ranging from 50.3% (1998) to 59.2% (2010), and the mean age at time of diagnosis was 47–50 years. We identified a total of 12 719 patients with PsA (prevalence=0.22%), including 9034 patients where the PsA diagnosis was made by a rheumatologist (prevalence=0.16%). Incidence rates of PsA (per 100 000 person-years) increased from 7.3 in 1997 to a peak incidence of 27.3 in 2010. Incidence rates were highest for women and patients aged 50–59 years, respectively. The use of systemic non-biologic agents, that is, methotrexate, leflunomide, ciclosporin or sulfasalazine increased over the 15-year study course and were used in 66.3% of all patients. Biologic agents (etanercept, infliximab, adalimumab, certolizumab pegol, golimumab or ustekinumab) were used in 17.7% of patients with PsA.ConclusionsWe found a clear trend of rising PsA incidence on a national level. While the cause remains unclear, our findings might be explained by increased attention by patients and physicians.
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Egeberg, A
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Kristensen, LE
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Thyssen, JP
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Gislason, GH
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Gottlieb, AB
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Coates, LC
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show more...
-
Jullien, D
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Gisondi, P
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Gladman, DD
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Skov, L
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Mallbris, L
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show less...
- Articles in the publication
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Annals of the rh ...
- By the university
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Karolinska Institutet