Search: onr:"swepub:oai:prod.swepub.kib.ki.se:136434704" >
The non-coding RNA ...
The non-coding RNA BC1 regulates experience-dependent structural plasticity and learning
-
Briz, V (author)
-
Restivo, L (author)
-
Pasciuto, E (author)
-
show more...
-
Juczewski, K (author)
-
Mercaldo, V (author)
-
Lo, AC (author)
-
Baatsen, P (author)
-
Gounko, NV (author)
-
Borreca, A (author)
-
Girardi, T (author)
-
Luca, R (author)
-
Nys, J (author)
-
Poorthuis, RB (author)
-
Mansvelder, HD (author)
-
- Fisone, G (author)
- Karolinska Institutet
-
Ammassari-Teule, M (author)
-
Arckens, L (author)
-
Krieger, P (author)
-
Meredith, R (author)
-
Bagni, C (author)
-
show less...
-
(creator_code:org_t)
- 2017-08-17
- 2017
- English.
-
In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8:1, s. 293-
- Related links:
-
https://www.nature.c...
-
show more...
-
http://kipublication...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- The brain cytoplasmic (BC1) RNA is a non-coding RNA (ncRNA) involved in neuronal translational control. Absence of BC1 is associated with altered glutamatergic transmission and maladaptive behavior. Here, we show that pyramidal neurons in the barrel cortex of BC1 knock out (KO) mice display larger excitatory postsynaptic currents and increased spontaneous activity in vivo. Furthermore, BC1 KO mice have enlarged spine heads and postsynaptic densities and increased synaptic levels of glutamate receptors and PSD-95. Of note, BC1 KO mice show aberrant structural plasticity in response to whisker deprivation, impaired texture novel object recognition and altered social behavior. Thus, our study highlights a role for BC1 RNA in experience-dependent plasticity and learning in the mammalian adult neocortex, and provides insight into the function of brain ncRNAs regulating synaptic transmission, plasticity and behavior, with potential relevance in the context of intellectual disabilities and psychiatric disorders.
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Briz, V
-
Restivo, L
-
Pasciuto, E
-
Juczewski, K
-
Mercaldo, V
-
Lo, AC
-
show more...
-
Baatsen, P
-
Gounko, NV
-
Borreca, A
-
Girardi, T
-
Luca, R
-
Nys, J
-
Poorthuis, RB
-
Mansvelder, HD
-
Fisone, G
-
Ammassari-Teule, ...
-
Arckens, L
-
Krieger, P
-
Meredith, R
-
Bagni, C
-
show less...
- Articles in the publication
-
Nature communica ...
- By the university
-
Karolinska Institutet