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Meta-signature of h...
Meta-signature of human endometrial receptivity: a meta-analysis and validation study of transcriptomic biomarkers
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Altmae, S (author)
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Koel, M (author)
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Vosa, U (author)
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Adler, P (author)
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Suhorutsenko, M (author)
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Laisk-Podar, T (author)
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Kukushkina, V (author)
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Saare, M (author)
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Velthut-Meikas, A (author)
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Krjutskov, K (author)
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Aghajanova, L (author)
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- Lalitkumar, PG (author)
- Karolinska Institutet
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- Gemzell-Danielsson, K (author)
- Karolinska Institutet
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Giudice, L (author)
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Simon, C (author)
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Salumets, A (author)
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(creator_code:org_t)
- 2017-08-30
- 2017
- English.
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In: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 7:1, s. 10077-
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https://www.nature.c...
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Abstract
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- Previous transcriptome studies of the human endometrium have revealed hundreds of simultaneously up- and down-regulated genes that are involved in endometrial receptivity. However, the overlap between the studies is relatively small, and we are still searching for potential diagnostic biomarkers. Here we perform a meta-analysis of endometrial-receptivity associated genes on 164 endometrial samples (76 from ‘pre-receptive’ and 88 from mid-secretory, ‘receptive’ phase endometria) using a robust rank aggregation (RRA) method, followed by enrichment analysis, and regulatory microRNA prediction. We identify a meta-signature of endometrial receptivity involving 57 mRNA genes as putative receptivity markers, where 39 of these we confirm experimentally using RNA-sequencing method in two separate datasets. The meta-signature genes highlight the importance of immune responses, the complement cascade pathway and the involvement of exosomes in mid-secretory endometrial functions. Bioinformatic prediction identifies 348 microRNAs that could regulate 30 endometrial-receptivity associated genes, and we confirm experimentally the decreased expression of 19 microRNAs with 11 corresponding up-regulated meta-signature genes in our validation experiments. The 57 identified meta-signature genes and involved pathways, together with their regulatory microRNAs could serve as promising and sought-after biomarkers of endometrial receptivity, fertility and infertility.
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Altmae, S
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Koel, M
-
Vosa, U
-
Adler, P
-
Suhorutsenko, M
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Laisk-Podar, T
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show more...
-
Kukushkina, V
-
Saare, M
-
Velthut-Meikas, ...
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Krjutskov, K
-
Aghajanova, L
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Lalitkumar, PG
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Gemzell-Danielss ...
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Giudice, L
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Simon, C
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Salumets, A
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show less...
- Articles in the publication
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Scientific repor ...
- By the university
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Karolinska Institutet