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Association of a va...
Association of a variant in the gene encoding for ERV1/ChemR23 with reduced inflammation in visceral adipose tissue from morbidly obese individuals
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Lopez-Vicario, C (author)
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Rius, B (author)
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Alcaraz-Quiles, J (author)
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Gonzalez-Periz, A (author)
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Martinez-Puchol, AI (author)
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Casulleras, M (author)
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Duran-Guell, M (author)
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Ibarzabal, A (author)
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Corcelles, R (author)
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Laguna-Fernandez, A (author)
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- Back, M (author)
- Karolinska Institutet
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Titos, E (author)
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Claria, J (author)
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(creator_code:org_t)
- 2017-11-16
- 2017
- English.
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In: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 7:1, s. 15724-
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https://www.nature.c...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- Obesity comorbidities are closely associated with chronic low-grade adipose tissue inflammation. A number of SNPs associated with inflammation has been identified, underscoring the impact of genetic determinants on this process. Here, we screened SNPs in genes with pro-inflammatory (IL-1β, IL-6, STAT3 and JAK2), anti-inflammatory (IL-10 and SOCS3) and pro-resolving (ERV1/ChemR23) properties in 101 obese and 99 non-obese individuals. Among the SNPs analyzed, we identified that individuals carrying a C allele in the rs1878022 polymorphism of the ERV1/ChemR23 gene, which encodes for the receptor of the pro-resolving mediator RvE1, had increased ERV1/ChemR23 protein expression and reduced levels of the inflammatory cytokine IL-6 in adipose tissue. Moreover, patients carrying the C allele in homozygosity had lower plasma levels of IL-6, IFN-α2, IL-15, IL-1ra, IL-10, GM-CSF, G-CSF and VEGF and enhanced leukocyte responsiveness to RvE1. C-carriers also exhibited decreased TAG to HDL ratio, a surrogate marker of insulin resistance and a predictor of incident fatty liver. Finally, we confirmed in vivo that the ERV1/ChemR23 receptor regulates systemic and tissue inflammation since mice lacking ERV1/ChemR23 expression showed increased IL-6 levels in adipose tissue and peritoneal macrophages. Together, our study identified an ERV1/ChemR23 variant that protects patients with obesity from excessive inflammatory burden.
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- By the author/editor
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Lopez-Vicario, C
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Rius, B
-
Alcaraz-Quiles, ...
-
Gonzalez-Periz, ...
-
Martinez-Puchol, ...
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Casulleras, M
-
show more...
-
Duran-Guell, M
-
Ibarzabal, A
-
Corcelles, R
-
Laguna-Fernandez ...
-
Back, M
-
Titos, E
-
Claria, J
-
show less...
- Articles in the publication
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Scientific repor ...
- By the university
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Karolinska Institutet